Please use this identifier to cite or link to this item:
10.1210/jc.2011-0632
Title: | Genetically determined dosage of Follicle-Stimulating Hormone (FSH) affects male reproductive parameters |
Authors: | Grigorova, Marina Punab, Margus Ẑilaitiene, Birute Erenpreiss, Juris Ausmees, Kristo Matuleviĉius, Valentinas Tsarev, Igor Jørgensen, Niels Laan, Maris Rīga Stradiņš University |
Keywords: | 1.6 Biological sciences;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;Endocrinology, Diabetes and Metabolism;Biochemistry;Endocrinology;Clinical Biochemistry;Biochemistry, medical;SDG 3 - Good Health and Well-being |
Issue Date: | Sep-2011 |
Citation: | Grigorova , M , Punab , M , Ẑilaitiene , B , Erenpreiss , J , Ausmees , K , Matuleviĉius , V , Tsarev , I , Jørgensen , N & Laan , M 2011 , ' Genetically determined dosage of Follicle-Stimulating Hormone (FSH) affects male reproductive parameters ' , Journal of Clinical Endocrinology and Metabolism , vol. 96 , no. 9 , pp. E1534-E1541 . https://doi.org/10.1210/jc.2011-0632 |
Abstract: | Context: The detailed role of FSH in contributing to male testicular function and fertility has been debated. We have previously identified the association between the T-allele of the FSHB promoter polymorphism (rs10835638; G/T, -211 bp from the mRNA start) and significantly reduced male serum FSH. Objective: In the current study, the T-allele carriers of the FSHB -211 G/T single nucleotide polymorphism represented a natural model for documenting downstream phenotypic consequences of insufficient FSH action. Design and Subjects: We genotyped rs10835638 in the population-based Baltic cohort of young men (n=1054; GG carriers, n=796; GT carriers, n=244; TT carriers, n=14) recruited by Andrology Centres in Tartu, Estonia; Riga, Latvia; and Kaunas, Lithuania. Marker-trait association testing was performed using linear regression (additive, recessive models) adjusted by age, body mass index, smoking, and recruitment center. Results: Serum hormones directly correlated with the T-allele dosage of rs10835638 included FSH (additive model, P=1.11×10 -6; T-allele effect, -0.41 IU/liter), inhibin-B (P=2.16×10 -3; T-allele effect, -14.67 pg/ml), and total testosterone (P = 9.30 × 10 -3; T-allele effect, -1.46 nmol/liter). Parameters altered only among TT homozygotes were reduced testicular volume (recessive model, P = 1.19 × 10 -4; TT genotype effect, -9.47 ml) and increased serum LH (P = 2.25 × 10 -2; TT genotype effect, 1.07 IU/liter). The carrier status of rs10835638 alternative genotypes did not affect sperm motility and morphology, calculated free testosterone, serum SHBG, and estradiol concentrations. Conclusion: We showed for the first time that genetically determined low FSH may have wider downstream effects on the male reproductive system, including impaired testes development, altered testicular hormone levels (inhibin-B, total testosterone, LH), and affected male reproductive potential. |
DOI: | 10.1210/jc.2011-0632 |
ISSN: | 0021-972X |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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