Please use this identifier to cite or link to this item: 10.2478/prolas-2014-0024
Title: The role of oxidative stress markers in developing of acute respiratory distress syndrome
Authors: Sarkele, Marina
Ozoliņa, Agnese
Sabeļņikovs, Oļegs
Šķesters, Andrejs
Silova, Alise
Jaunalksne, Inta
Strīķe, Eva
Krūmiņa, Angelika
Vanags, Indulis
Department of Anaesthesiology and Intensive Care
Scientific Laboratory of Biochemistry
Department of Infectology
Keywords: acute respiratory distress syndrome;antioxidants;biomarkers;oxidants;oxidative stress markers;reactive oxygen species;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;General
Issue Date: 1-Dec-2014
Citation: Sarkele , M , Ozoliņa , A , Sabeļņikovs , O , Šķesters , A , Silova , A , Jaunalksne , I , Strīķe , E , Krūmiņa , A & Vanags , I 2014 , ' The role of oxidative stress markers in developing of acute respiratory distress syndrome ' , Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences , vol. 68 , no. 5-6 , pp. 200-206 . https://doi.org/10.2478/prolas-2014-0024
Abstract: Acute respiratory distress syndrome (ARDS) is common and multi factorial, clinically described as an inflammatory lung disorder that is associated with major morbidity and high mortality in intensive care patients. Recently, investigators have revised the AECC criteria from 1994. To diagnose ARDS and discover its severity we presently use Berlin definition criteria. An important role in developing of ARDS may be through a disbalance between reactive oxygen species (ROS), which have both oxidant and antioxidant compartments. The pathogenesis of ARDS is very complex, and unfortunately, the dynamic development of ARDS in an individual patient is difficult to recognise. ROS can initiate cellular tissue damage by modifying lipids, proteins and DNA, which can seriously compromise cell life ability or induce a large number of cellular responses through generation of secondary reactive species, leading, at last, to cell death by necrosis or apoptosis. Studies have shown that many patients with organ malfunction at admission to the intensive care units (ICU) show decreased antioxidative properties, worsening the harmful effects of lipid peroxidation. That is the reason why predicting development of ARDS has great value for intensive care specialists.
Description: Publisher Copyright: © by Marina arkele 2015.
DOI: 10.2478/prolas-2014-0024
ISSN: 1407-009X
Appears in Collections:Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure

Files in This Item:
File SizeFormat 
The_role_of_oxidative_stress_markers.pdf97.35 kBAdobe PDFView/Openopen_acces_unlocked


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.