Please use this identifier to cite or link to this item:
10.2478/prolas-2014-0032
Title: | The activity of oxidative stress markers in acute respiratory distress syndrome |
Authors: | Šarkele, Marina Ozoliņa, Agnese Sabeļņikovs, Oļegs Šķesters, Andrejs Silova, Alise Vanags, Indulis Department of Anaesthesiology and Intensive Care Scientific Laboratory of Biochemistry |
Keywords: | ARDS;oxidative stress;reactive oxygen species;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;General |
Issue Date: | 1-Dec-2014 |
Citation: | Šarkele , M , Ozoliņa , A , Sabeļņikovs , O , Šķesters , A , Silova , A & Vanags , I 2014 , ' The activity of oxidative stress markers in acute respiratory distress syndrome ' , Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences , vol. 68 , no. 5-6 , pp. 247-249 . https://doi.org/10.2478/prolas-2014-0032 |
Abstract: | Acute respiratory distress syndrome is a common complication characterised by severe hypoxemia, which leads to high mortality rates in ICU patients. Imbalance between oxidative stress markers like oxidants and antioxidants may play an important role in pathophysiology of the syndrome. We observed 17 ARDS patients during seven days after inclusion, with the main goal to describe dynamic changes in the level of oxidative stress markers in patients with acute respiratory distress syndrome. We found that there are dynamic differences in the level of malondialdechyde (MDA) and nitric oxide (NO) in patients with acute respiratory distress syndrome. There were also different levels of oxidative stress markers in non-survivor compared with survivor groups. Increased level of an oxidant like a thiobarbituric acid substance with malondialdechyde (TBS-MDA) and antioxidant glutathionperoxidase (GPx) at the first day after inclusion was related with poor outcome in patients with acute respiratory distress syndrome. |
Description: | Publisher Copyright: © by Marina Šarkele 2015. |
DOI: | 10.2478/prolas-2014-0032 |
ISSN: | 1407-009X |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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