Please use this identifier to cite or link to this item:
10.3390/medicina48060047
Title: | The first evidence of hereditary and familial gastric cancer in Latvia : Implications for prevention |
Authors: | Vanags, Andrejs Štrumfa, Ilze Gardovskis, Andris Aboliņs, Arnis Simtniece, Zane Trofimovičs, Genadijs Gardovskis, Janis Department of Surgery Department of Pathology |
Keywords: | Familial gastric cancer;Hereditary cancer;Hereditary gastric cancer;Population screening;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;General Medicine;SDG 3 - Good Health and Well-being |
Issue Date: | 2012 |
Citation: | Vanags , A , Štrumfa , I , Gardovskis , A , Aboliņs , A , Simtniece , Z , Trofimovičs , G & Gardovskis , J 2012 , ' The first evidence of hereditary and familial gastric cancer in Latvia : Implications for prevention ' , Medicina (Lithuania) , vol. 48 , no. 6 , pp. 317-323 . https://doi.org/10.3390/medicina48060047 |
Abstract: | Background and Objective: Gastric cancer is a frequent cause of cancer mortality. The prognosis of established tumor is unfavorable due to the propensity to spread and limited treatment efficiency. Therefore, prevention has a high significance. We tested a population screening approach in order to identify families with an increased gastric cancer load for further surveillance. Material and Methods: Population screening was performed by questionnaire reaching 76.6% of the population. Hereditary gastric cancer (HGC) syndrome was diagnosed if 3 mutually first-degree relatives with gastric cancer were reported in the kindred. Additional group (HGC2) of families with 2 first-degree relatives affected by gastric cancer was identified. Results: The HGC syndrome was diagnosed in 0.11%, but HGC2 syndrome, in 0.4% probands. The gastric cancer frequency among blood relatives was 25.2% (95% CI, 20.6%-30.4%) in HGC, but 16.0% (95% CI, 13.8%-18.5%) in HGC2 families. The mean age at diagnosis of cancer was 56.9 years (95% CI, 53.4-60.3) in HGC and 62.5 years (95% CI, 60.1-64.8) in HGC2. The mean survival was 2.6 years (95% CI, 1.2-4.0). Conclusions: Population screening identifies reasonable number of families with a high frequency of gastric cancer. The frequency of gastric cancer and an unfavorable course characterized by low survival justify surveillance in families with 2 or 3 first-degree relatives affected by gastric cancer. Population screening provides the age characteristics of the respective tumors in order to adjust the surveillance schedule. |
DOI: | 10.3390/medicina48060047 |
ISSN: | 1010-660X |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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The_first_evidence_of_hereditary_and_familial_gastric_cancer.pdf | 237.84 kB | Adobe PDF | View/Open |
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