Please use this identifier to cite or link to this item:
10.3390/medicina49070051
Title: | Vitamin D status and its seasonal variations and association with parathyroid hormone concentration in healthy women in Riga |
Authors: | Lejnieks, Aivars Slaidina, Anda Zvaigzne, Agnis Soboleva, Una Eivazova, Gulsena Daukste, Ilze Lejniece, Sandra Rīga Stradiņš University Department of Prosthetic Dentistry |
Keywords: | Parathyroid hormone;Vitamin D;Vitamin D deficiency;3.2 Clinical medicine;3.3 Health sciences;1.1. Scientific article indexed in Web of Science and/or Scopus database;General Medicine |
Issue Date: | 2013 |
Citation: | Lejnieks , A , Slaidina , A , Zvaigzne , A , Soboleva , U , Eivazova , G , Daukste , I & Lejniece , S 2013 , ' Vitamin D status and its seasonal variations and association with parathyroid hormone concentration in healthy women in Riga ' , Medicina (Lithuania) , vol. 49 , no. 7 , pp. 329-334 . https://doi.org/10.3390/medicina49070051 |
Abstract: | The aim of the study was to describe the vitamin D status and its seasonal variations in women living in Riga, Latvia, to examine an association between the concentrations of plasma 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH), and to determine the threshold for plasma 25(OH)D above which there is no further suppression of PTH. Material and Methods: The data of 189 healthy Caucasian women were analyzed. The serum levels of 25(OH)D, PTH, and phosphorus were measured twice a year. All the participants were divided into 3 groups according to vitamin D supplementation and the reproductive status. Results: The overall mean level of 25(OH)D was 32.8 ng/mL with significantly lower levels being in winter when compared with those in summer (28.2 ng/mL vs. 37.5 ng/mL, respectively; P>0.05). PTH was negatively associated with 25(OH)D. A threshold level of plasma 25(OH)D above which no further suppression of PTH occurred was found to be 38 ng/mL. Postmenopausal women not taking vitamin D supplements and without exposure to sunlight had 25(OH)D deficiency in winter and summer (92% and 88%, respectively). The most significant seasonal fluctuations were seen in the women of the reproductive age not taking vitamin D supplements and without exposure to sunlight, of which 47% had 25(OH)D deficiency in summer and 69% in winter. Conclusions: An optimal concentration of 25(OH)D was found to be 38 ng/mL. According to this definition, 70.4% of all the healthy women were classified as vitamin D deficient in winter and 59.8% in summer. The highest proportion of vitamin D deficient individuals was found in the group representing the postmenopausal women not taking vitamin D supplements. |
Description: | Copyright: Copyright 2020 Elsevier B.V., All rights reserved. |
DOI: | 10.3390/medicina49070051 |
ISSN: | 1010-660X |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Vitamin_D_Status_and_Its_Seasonal_Variations.pdf | 221.36 kB | Adobe PDF | View/Open |
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