Please use this identifier to cite or link to this item:
10.1515/prolas-2016-0033
Title: | Role of Interferon-Gamma (Ifn-γ) in Immune Response Regulation in HIV-1 and HIV-1 + Mycobacterium Tuberculosis (Tb) Infected Patients |
Authors: | Januškevica, Inga Rozentale, Baiba Hagina, Elvīra Eglīte, Jeļena Kolupajeva, Tatjana Storozenko, Jeļena Guseva, Ludmila Lejnieks, Aivars Department of Internal Diseases Joint Laboratory of Clinical Immunology and Immunogenetics Department of Infectology |
Keywords: | cytokines;HIV-1;IFN-γ;Mycobacterium tuberculosis;3.1 Basic medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;General;SDG 3 - Good Health and Well-being |
Issue Date: | 1-Aug-2016 |
Citation: | Januškevica , I , Rozentale , B , Hagina , E , Eglīte , J , Kolupajeva , T , Storozenko , J , Guseva , L & Lejnieks , A 2016 , ' Role of Interferon-Gamma (Ifn-γ) in Immune Response Regulation in HIV-1 and HIV-1 + Mycobacterium Tuberculosis (Tb) Infected Patients ' , Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences , vol. 70 , no. 4 , pp. 211-214 . https://doi.org/10.1515/prolas-2016-0033 |
Abstract: | The aim of this research was to investigate the role of IFN-γ in interaction between IL-10, IL-18, IL-1b, CD4 cell counts and HIV-1 RNA viral load in the development of HIV-1 in patients co-infected with Mycobacterium tuberculosis (TB). The study was conducted by Rīga East Clinical University Hospital with data from the HIV-1 register, in collaboration with the RSU Joint Laboratory of Clinical Immunology and Immunogenetics. 200 HIV-1 infected patients and 184 HIV-1 with TB co-infection patients divided in four groups were included in the study. IFN-γ, IL-10, IL-18, IL-1b levels were measured in serum with commercially enzyme-linked immunosorbent assay (ELISA Vector-Best Corporation, Novosibirsk, Russia). CD4 cell counts were measured by flow Partec IVD cytometry (USA). HIV-1 RNA quantification was performed using the COBAS AmpliPrep/COBAS Taqman HIV-1 Test (Germany). All groups were compared with each another. IFN-γ production was significantly lower, and IL-10 and CD4 cell counts were significantly higher, in HIV-1 patients without TB compared with the other groups. The group with HIV-1 and TB had significantly elevated IL-18 production. HIV patients with primary TB had significantly elevated IFN-γ production and HIV-1 RNA viral load and significantly lower IL-10 production. |
Description: | Publisher Copyright: © 2016 by Inga Januškevica. Copyright: Copyright 2016 Elsevier B.V., All rights reserved. |
DOI: | 10.1515/prolas-2016-0033 |
ISSN: | 1407-009X |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Role_of_Interferon_Gamma_Ifn_in_Immune_Response.pdf | 434.61 kB | Adobe PDF | View/Open |
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