Please use this identifier to cite or link to this item: 10.2337/db09-1166
Title: Maternal age at birth and childhood type 1 diabetes : A pooled analysis of 30 observational studies
Authors: Cardwell, Chris R.
Stene, Lars C.
Joner, Geir
Bulsara, Max K.
Cinek, Ondrej
Rosenbauer, Joachim
Ludvigsson, Johnny
Jané, Mireia
Svensson, Jannet
Goldacre, Michael J.
Waldhoer, Thomas
Jarosz-Chobot, Przemysława
Gimeno, Suely G.A.
Chuang, Lee Ming
Parslow, Roger C.
Wadsworth, Emma J.K.
Chetwynd, Amanda
Pozzilli, Paolo
Brigis, Girts
Urbonaite, Brone
Šipetić, Sandra
Schober, Edith
Devoti, Gabriele
Ionescu-Tirgoviste, Constantin
De Beaufort, Carine E.
Stoyanov, Denka
Buschard, Karsten
Patterson, Chris C.
Department of Public Health and Epidemiology
Keywords: 3.2 Clinical medicine;3.3 Health sciences;1.1. Scientific article indexed in Web of Science and/or Scopus database;Internal Medicine;Endocrinology, Diabetes and Metabolism;SDG 3 - Good Health and Well-being
Issue Date: Feb-2010
Citation: Cardwell , C R , Stene , L C , Joner , G , Bulsara , M K , Cinek , O , Rosenbauer , J , Ludvigsson , J , Jané , M , Svensson , J , Goldacre , M J , Waldhoer , T , Jarosz-Chobot , P , Gimeno , S G A , Chuang , L M , Parslow , R C , Wadsworth , E J K , Chetwynd , A , Pozzilli , P , Brigis , G , Urbonaite , B , Šipetić , S , Schober , E , Devoti , G , Ionescu-Tirgoviste , C , De Beaufort , C E , Stoyanov , D , Buschard , K & Patterson , C C 2010 , ' Maternal age at birth and childhood type 1 diabetes : A pooled analysis of 30 observational studies ' , Diabetes , vol. 59 , no. 2 , pp. 486-494 . https://doi.org/10.2337/db09-1166
Abstract: OBJECTIVE - The aim if the study was to investigate whether children born to older mothers have an increased risk of type 1 diabetes by performing a pooled analysis of previous studies using individual patient data to adjust for recognized confounders. RESEARCH DESIGN AND METHODS - Relevant studies published before June 2009 were identified from MEDLINE, Web of Science, and EMBASE. Authors of studies were contacted and asked to provide individual patient data or conduct prespecified analyses. Risk estimates of type 1 diabetes by maternal age were calculated for each study, before and after adjustment for potential confounders. Meta-analysis techniques were used to derive combined odds ratios and to investigate heterogeneity among studies. RESULTS - Data were available for 5 cohort and 25 case-control studies, including 14,724 cases of type 1 diabetes. Overall, there was, on average, a 5% (95% CI 2-9) increase in childhood type 1 diabetes odds per 5-year increase in maternal age (P = 0.006), but there was heterogeneity among studies (heterogeneity I2 = 70%). In studies with a low risk of bias, there was a more marked increase in diabetes odds of 10% per 5-year increase in maternal age. Adjustments for potential confounders little altered these estimates. CONCLUSIONS - There was evidence of a weak but significant linear increase in the risk of childhood type 1 diabetes across the range of maternal ages, but the magnitude of association varied between studies. A very small percentage of the increase in the incidence of childhood type 1 diabetes in recent years could be explained by increases in maternal age.
DOI: 10.2337/db09-1166
ISSN: 0012-1797
Appears in Collections:Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure

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