Please use this identifier to cite or link to this item: 10.3390/medicina55090510
Title: Venous thromboembolism recurrence in Latvian population : Single university hospital data
Authors: Gībietis, Valdis
Kigitoviča, Dana
Strautmane, Sintija
Meilande, Kitija
Kalējs, Verners Roberts
Zaičenko, Anastasija
Make, Kristīne
Lejnieks, Aivars
Skride, Andris
Department of Internal Diseases
Keywords: Anticoagulation;Cancer;Pulmonary embolism;Recurrence;Venous thromboembolism;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;General Medicine;SDG 3 - Good Health and Well-being
Issue Date: Sep-2019
Citation: Gībietis , V , Kigitoviča , D , Strautmane , S , Meilande , K , Kalējs , V R , Zaičenko , A , Make , K , Lejnieks , A & Skride , A 2019 , ' Venous thromboembolism recurrence in Latvian population : Single university hospital data ' , Medicina (Lithuania) , vol. 55 , no. 9 , 510 . https://doi.org/10.3390/medicina55090510
Abstract: Background and objectives: Recurrence of venous thromboembolism (VTE) after a primary event is common; however, no sufficient risk scores have been widely introduced in clinical practice. The aim of this study was to assess the risk factors for VTE recurrences, as well as the effect of treatment strategies on the recurrence rate in a single-center patient cohort. Materials and Methods: The prospective cohort study included consecutive patients in a single center from June 2014 till June 2018 presenting with acute VTE confirmed by imaging tests. All patients were followed up for at least one year or till death. Statistical analyses were conducted using IBM SPSS Statistics 23 and Stata 13. Competing risk of death was considered. Results: A total of 219 eligible patients were identified during the study period. Pulmonary embolism with or without deep vein thrombosis (DVT) was present in 95.9% (n = 210), isolated DVT was present in 4.1% (n = 9) of patients. The total number of documented recurrences was 13 (5.9%). Incidence rate was 5.6 per 100 person-years. Recurrent VTE predicted significantly higher mortality rate (hazard ratio (HR) 6.64 [95% CI 2.61-16.93]). In univariate analysis, active cancer was associated with higher recurrence rate (p = 0.036). In competing-risks regression model (with death as the competing risk), active cancer (subdistribution hazard ratio (SHR) 2.11 (95% CI 0.58-7.76)) did not retain statistical significance for VTE recurrence. Discontinuation and duration of anticoagulant treatment (≤6 or >6 months), and drug class in acute or long-term therapy (parenteral, vitamin K antagonist (VKA), direct oral anticoagulant (DOAC)) were not associated with recurrences (p > 0.05). Conclusions: Patients who experienced recurrent VTE had 6.6-fold higher mortality rate than patients with no recurrences. The presence of active cancer was not a statistically significant risk factor for recurrence when taking into account the competing risk of death. Duration and drug class of anticoagulation did not seem to impact recurrence rate.
Description: Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
DOI: 10.3390/medicina55090510
ISSN: 1010-660X
Appears in Collections:Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure

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