Please use this identifier to cite or link to this item:
10.2478/prolas-2019-0062
Title: | Association of non-invasive markers of liver fibrosis with HCV coinfection and antiretroviral therapy in patients with HIV |
Authors: | Koļesova, Oksana Eglite, Jeļena Koļesovs, Aleksandrs Krumiņa, Angelika Ekšteina, Ilze Madelane, Monta Viksna, Ludmila Joint Laboratory of Clinical Immunology and Immunogenetics Department of Infectology |
Keywords: | ALT;AST;FIB-4;hyaluronic acid;liver fibrosis;nonparametric ANOVA;pro-MMP-1;3.2 Clinical medicine;3.3 Health sciences;1.1. Scientific article indexed in Web of Science and/or Scopus database;General;SDG 3 - Good Health and Well-being |
Issue Date: | 1-Aug-2019 |
Citation: | Koļesova , O , Eglite , J , Koļesovs , A , Krumiņa , A , Ekšteina , I , Madelane , M & Viksna , L 2019 , ' Association of non-invasive markers of liver fibrosis with HCV coinfection and antiretroviral therapy in patients with HIV ' , Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences , vol. 73 , no. 4 , pp. 400-402 . https://doi.org/10.2478/prolas-2019-0062 |
Abstract: | The aim of this study was to assess the main effects and interaction between viral hepatitis C (HCV) coinfection and antiretroviral therapy (ART) by using a nonparametric ANOVA on direct and indirect markers of liver fibrosis in HIV-infected patients. The sample included 178 HIV patients aged from 23 to 65 (36% females). The following parameters were determined in blood of patients: hyaluronic acid, pro-matrix metalloproteinase-1, alanine aminotransferase, aspartate aminotransferase, and platelet count. The FIB-4 index was also calculated. The nonparametric ANOVA revealed no significant interaction between HCV coinfection and ART. This provides evidence for an independent contribution of each factor on promotion of the pathology. The results also demonstrated that the direct and indirect indicators of liver fibrosis are associated differently with the studied factors. Therefore, a combination of markers should be used for monitoring of liver fibrosis in HIV-infected patients. |
Description: | Publisher Copyright: © 2019 Oksana Koļesova et al., published by Sciendo 2019. Copyright: Copyright 2019 Elsevier B.V., All rights reserved. |
DOI: | 10.2478/prolas-2019-0062 |
ISSN: | 1407-009X |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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ASSOCIATION_OF_NON_INVASIVE_MARKERS_OF_LIVER.pdf | 80.44 kB | Adobe PDF | View/Open |
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