Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Rasa-Dzelzkalēja, Santa | - |
dc.contributor.author | Čapenko, Svetlana | - |
dc.contributor.author | Krūmiņa, Angelika | - |
dc.contributor.author | Yung-Cheng, Lin | - |
dc.contributor.author | Murovska, Modra | - |
dc.date.accessioned | 2021-01-14T07:42:35Z | - |
dc.date.available | 2021-01-14T07:42:35Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/2899 | - |
dc.description.abstract | Our aim was to estimate the presence of B19V infection markers, the level of cytokines and time period since the appearance of infection in association with ME/CFS clinical symptoms. In 200 ME/CFS patients and 104 control group individuals the presence of B19V-specific IgG/IgM class antibodies, B19V NS1 gene sequence, mRNA expression, viral load and level of cytokines were determined. B19V-specific IgG-antibodies were found in 70% of ME/CFS patients and 67.4% of controls, IgM-antibodies in 8% of patients and in none of controls, B19V genomic sequences in 29% of patients and 3.8% of controls. 58.6% of positive patients had active and 41.4% had latent/persistent B19V infection. B19V NS1 gene expression was detected in 43% of patients. B19V load varied from < 0.2 copies to median 38.2 copies/µg of DNA. According to the antibody pattern, 36% of patients had a recent, and 43% had sustained B19V infection. Patients with the B19V genomic sequence and NS1 specific antibodies significantly more often had lymphadenopathy and multi-joint pain. Onset of the symptoms corresponded to time of appearance of B19V infection. IL-10 and TNF-levels were higher in patients with elevated B19V load. B19V genome 1 was identified in Latvian ME/CFS patients. The results indicated that at least in some cases B19V infection plays an important role in ME/CFS development | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. | Volume 73: Issue 5; DOI: https://doi.org/10.2478/prolas-2019-0065 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | human parvovirus B19 | en_US |
dc.subject | myalgic encephalomyelitis | en_US |
dc.subject | chronic fatigue syndrome | en_US |
dc.title | Association of Human Parvovirus B19 Infection with Development and Clinical Course of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome | en_US |
dc.type | Article | en_US |
Appears in Collections: | Publications |
Files in This Item:
File | Description | Size | Format | |
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Association of Human Parvovirus B19 Infection with Development and Clinical Course of Myalgic Encephalomyelitis Chronic Fatigue Syndrome.pdf | 498.8 kB | Adobe PDF | View/Open |
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