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dc.contributor.authorKadiša, Anda-
dc.contributor.authorNora-Krūkle, Zaiga-
dc.contributor.authorŠvirskis, Simons-
dc.contributor.authorStuders, Pēteris-
dc.contributor.authorGirkontaite, Irute-
dc.contributor.authorLejnieks, Aivars-
dc.contributor.authorMurovska, Modra-
dc.date.accessioned2021-01-13T13:16:38Z-
dc.date.available2021-01-13T13:16:38Z-
dc.date.issued2019-
dc.identifier.issn2255-890X-
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/2897-
dc.description.abstractRheumatoid arthritis (RA) is a chronic autoimmune disease that causes erosive changes and ankylosis of joints and may cause internal injuries. Osteoarthritis (OA) is a degenerative process of the articular cartilage. However, inflammatory mediators may play a pivotal role in the initiation and perpetuation of the OA process. It is necessary to continue to study possible factors that may promote the development of the disease. The goal of this study was to evaluate the frequency and activity stage of parvovirus B19 (B19V) and persistent human herpes virus (HHV)-6 and HHV-7 infection in RA and OA patients, and healthy persons, in relation to cytokine levels and presence or absence of viral infections. RA patients with active B19V infection had the highest levels of tumour necrosis factor alpha (TNF-α), which may contribute to the development of RA. In the case of OA, the TNF-α level was higher in patients with active persistent B19V infection, suggesting that B19V reactivation affects also OA. Interleukin (IL)-6, IL-10 and metalloproteinase (MMP)-9 levels were higher in RA patients with latent HHV-6/-7 infection in comparison with active HHV-6/-7 infection, whereas in OA patients levels of all studied cytokines were very variable, ranging from low to high but without significant differences. This suggests that also latent HHV-6 and -7 viral infections can promote development of RA.en_US
dc.language.isoenen_US
dc.relation.ispartofProceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. | Volume 73: Issue 4; DOI: https://doi.org/10.2478/prolas-2019-0045en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectarthritisen_US
dc.subjectB19Ven_US
dc.subjectherpes virusesen_US
dc.subjectcytokinesen_US
dc.subjectMMP-9en_US
dc.titleCytokines and MMP-9 Levels in Rheumatoid Arthritis and Osteoarthritis Patients with Persistent Parvovirus B19, HHV-6 and HHV-7 Infectionen_US
dc.typeArticleen_US
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