Please use this identifier to cite or link to this item: https://doi.org/10.25143/prom-rsu_2015-11_dts
Title: Characterization of Hereditary Endometrial Cancer in Latvia. Summary of the Doctoral Thesis
Other Titles: Pārmantotā endometrija vēža raksturojums Latvijā. Promocijas darba kopsavilkums
Authors: Gardovskis, Jānis
Švampāne, Liāna
Keywords: Medicine, Subsection – Oncology;Summary of the Doctoral Thesis
Issue Date: 2015
Publisher: Rīga Stradiņš University
Citation: Švampāne, L. 2015. Characterization of Hereditary Endometrial Cancer in Latvia: Summary of the Doctoral Thesis: Subsection – Oncology. Rīga: Rīga Stradiņš University. https://doi.org/10.25143/prom-rsu_2015-11_dts
Abstract: Endometrial cancer is one of the most common cancer localizations for women in many countries, mostly being 3rd after breast and skin cancer. In Latvia, endometrial cancer is first diagnosed in 370–390 women every year. 75% of those are women during menopause or postmenopause, whereas 25% are during premenopause. Therefore, early diagnosis is important in which expanded family history on endometrial or colorectal cancer morbity for first and second degree relatives is used by employing certain diagnostic criteria. The goal of this study was to detect possible hereditary endometrial cancer cases after oncological family history in patients with histologically verified endometrial cancer. Determine predisposing mutations in families with endometrial cancer as well as the expressions of the MSH2 and MSH6 genes in the case of hereditary and sporadic cancer. The study includes 704 patients whose age of disease onset, stage, degree of differentiation, survival and cancer activation were registered to compare hereditary endometrial cancer with sporadic cancer. According to the Amsterdam criteria, 19 patients were diagnosed with hereditary endometrial cancer while 685 – with sporadic endometrial cancer. 11/19 (57.9%) patients had predisposing mutations. 8/11 (72.7%) of these patients had overall 2 frameshift mutations (2150TCAG (rs63750159) and 1050delC) in the MSH6 gene, 3 missense mutations in the MLH1 (P640S (rs63749792) and 1219V (rs1799977)) gene and MSH2 (G322D (rs4987188)) gene, 1 splice-site mutation (IV5+A>T) in the MSH2 gene. 2 patients had no clicinally putative significant mutations. The incidence of endometrial cancer in consecutively hospitalized endometrial cancer patients is 2.7% (95% CI: 1.7–4.2%). The results show that detecting hereditary endometrial cancer can aid in early endometrial cancer diagnosis, therapy and prevention.
Description: Thesis has been developed at Riga Eastern Clinical University Hospital, Latvian Oncology Centre. Defence: at the public session of the Doctoral Committee of Medicine on 8 July, 2015 at 14.00 in Rīga, 16 Dzirciema Street, Rīga Stradiņš University, at the Hippocrates Lecture Theatre.
DOI: https://doi.org/10.25143/prom-rsu_2015-11_dts
License URI: http://creativecommons.org/licenses/by-nc/4.0/
Appears in Collections:2015.–2019. gadā aizstāvētie promocijas darbi un kopsavilkumi

Files in This Item:
File SizeFormat 
2015-11_Shvampaane-Liaana_DTS_15-139.pdf691.61 kBAdobe PDFView/Openopen_acces_unlocked


This item is licensed under a Creative Commons License Creative Commons