Please use this identifier to cite or link to this item:
10.1016/j.ijheh.2024.114378
Title: | Phthalates and substitute plasticizers : Main achievements from the European human biomonitoring initiative HBM4EU |
Authors: | Gerofke, Antje Lange, Rosa Vogel, Nina Schmidt, Phillipp Weber, Till David, Madlen Frederiksen, Hanne Baken, Kirsten Govarts, Eva Gilles, Liese Martin, Laura Rodriguez Martinsone, Žanna Santonen, Tiina Schoeters, Greet Scheringer, Martin Domínguez-Romero, Elena López, Marta Esteban Calvo, Argelia Castaño Koch, Holger M. Apel, Petra Kolossa-Gehring, Marike Institute of Occupational Safety and Environmental Health |
Keywords: | Exposure;HBM4EU;Human biomonitoring (HBM);Phthalates;Science-policy transfer;Substitute plasticizers;3.3 Health sciences;1.1. Scientific article indexed in Web of Science and/or Scopus database;Public Health, Environmental and Occupational Health |
Issue Date: | Jun-2024 |
Citation: | Gerofke , A , Lange , R , Vogel , N , Schmidt , P , Weber , T , David , M , Frederiksen , H , Baken , K , Govarts , E , Gilles , L , Martin , L R , Martinsone , Ž , Santonen , T , Schoeters , G , Scheringer , M , Domínguez-Romero , E , López , M E , Calvo , A C , Koch , H M , Apel , P & Kolossa-Gehring , M 2024 , ' Phthalates and substitute plasticizers : Main achievements from the European human biomonitoring initiative HBM4EU ' , International Journal of Hygiene and Environmental Health , vol. 259 , 114378 . https://doi.org/10.1016/j.ijheh.2024.114378 |
Abstract: | Phthalates and the substitute plasticizer DINCH belong to the first group of priority substances investigated by the European Human Biomonitoring Initiative (HBM4EU) to answer policy-relevant questions and safeguard an efficient science-to-policy transfer of results. Human internal exposure levels were assessed using two data sets from all European regions and Israel. The first collated existing human biomonitoring (HBM) data (2005–2019). The second consisted of new data generated in the harmonized “HBM4EU Aligned Studies” (2014–2021) on children and teenagers for the ten most relevant phthalates and DINCH, accompanied by a quality assurance/quality control (QA/QC) program for 17 urinary exposure biomarkers. Exposures differed between countries, European regions, age groups and educational levels. Toxicologically derived Human biomonitoring guidance values (HBM-GVs) were exceeded in up to 5% of the participants of the HBM4EU Aligned Studies. A mixture risk assessment (MRA) including five reprotoxic phthalates (DEHP, DnBP, DiBP, BBzP, DiNP) revealed that for about 17% of the children and teenagers, health risks cannot be excluded. Concern about male reproductive health emphasized the need to include other anti-androgenic substances for MRA. Contaminated food and the use of personal care products were identified as relevant exposure determinants paving the way for new regulatory measures. Time trend analyses verified the efficacy of regulations: especially for the highly regulated phthalates exposure dropped significantly, while levels of the substitutes DINCH and DEHTP increased. The HBM4EU e-waste study, however, suggests that workers involved in e-waste management may be exposed to higher levels of restricted phthalates. Exposure-effect association studies indicated the relevance of a range of endpoints. A set of HBM indicators was derived to facilitate and accelerate science-to-policy transfer. Result indicators allow different groups and regions to be easily compared. Impact indicators allow health risks to be directly interpreted. The presented results enable successful science-to-policy transfer and support timely and targeted policy measures. |
Description: | Publisher Copyright: © 2024 The Authors |
DOI: | 10.1016/j.ijheh.2024.114378 |
ISSN: | 1438-4639 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Phthalates_and_substitute_plasticizers.pdf | 3.07 MB | Adobe PDF | View/Open |
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