Please use this identifier to cite or link to this item:
10.3390/diagnostics14070717
Title: | Deceased Kidney Donor Biomarkers : Relationship between Delayed Kidney Function and Graft Function Three Years after Transplantation |
Authors: | Maslauskiene, Rima Vaiciuniene, Ruta Tretjakovs, Pēteris Gersone, Gita Radzeviciene, Aurelija Bura, Andrejus Stankevicius, Edgaras Bumblyte, Inga Arune Department of Human Physiology and Biochemistry |
Keywords: | CXCL10;donor biomarker;IL-18;kidney transplantation;KIM-1;NGAL;3.1 Basic medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;Clinical Biochemistry |
Issue Date: | Apr-2024 |
Citation: | Maslauskiene , R , Vaiciuniene , R , Tretjakovs , P , Gersone , G , Radzeviciene , A , Bura , A , Stankevicius , E & Bumblyte , I A 2024 , ' Deceased Kidney Donor Biomarkers : Relationship between Delayed Kidney Function and Graft Function Three Years after Transplantation ' , Diagnostics , vol. 14 , no. 7 , 717 . https://doi.org/10.3390/diagnostics14070717 |
Abstract: | With an increasing number of marginal donors, additional methods for the evaluation of cadaveric kidney quality are required. This study aimed to evaluate pretransplant deceased donor serum (s) and urine (u) biomarkers, including neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), interleukin-18, and C-X-C motif chemokine 10 (CXCL10) for predicting early and late graft function. In total, 43 deceased kidney donors and 76 corresponding recipients were enrolled. Delayed graft function (DGF) occurred in 27.6% of cases. sIL-18, sKIM-1, uNGAL, and uKIM-1 were predictors of DGF. A model incorporating sIL-18, uKIM-1, and clinical factors was developed to predict DGF (AUROC 0.863). Univariate analysis showed a negative association between uKIM and graft eGFR at 6, 12, 24, and 36 months, but this was not confirmed in the multivariate analysis. In conclusion, we report a superior performance of donor biomarkers for predicting DGF and later graft function over serum creatinine. Higher levels of donor sIL-18 and uKIM in conjunction with expanded-criteria donors and longer cold ischemia times predicted DGF. With no renal tubular damage in zero-time donor biopsies, higher pretransplant urine and serum NGAL levels were associated with better allograft function one year after transplantation, and sNGAL with graft function three years after transplantation. |
Description: | Publisher Copyright: © 2024 by the authors. |
DOI: | 10.3390/diagnostics14070717 |
ISSN: | 2075-4418 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
Files in This Item:
File | Size | Format | |
---|---|---|---|
Deceased_kidney_donor_biomarkers.pdf | 556.83 kB | Adobe PDF | View/Open![]() |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.