Please use this identifier to cite or link to this item:
10.3390/jcm12227133
Title: | Scheimpflug Corneal Densitometry Patterns at the Graft–Host Interface in DMEK and DSAEK : A 12-Month Longitudinal Comparative Study |
Authors: | Ballesteros-Sánchez, Antonio Peraza-Nieves, Jorge Casablanca-Piñera, Anna Rodríguez-Calvo-De-Mora, Marina Catalán-Coronado, Saray Torras-Sanvicens, Josep Borroni, Davide Sánchez-González, José María Rocha-De-Lossada, Carlos Department of Doctoral Studies Rīga Stradiņš University |
Keywords: | corneal densitometry;Descemet Membrane Endothelial Keratoplasty (DMEK);Descemet Stripping Automated Endothelial Keratoplasty (DSAEK);graft–host interface;3.2 Clinical medicine;1.1. Scientific article indexed in Web of Science and/or Scopus database;General Medicine |
Issue Date: | Nov-2023 |
Citation: | Ballesteros-Sánchez , A , Peraza-Nieves , J , Casablanca-Piñera , A , Rodríguez-Calvo-De-Mora , M , Catalán-Coronado , S , Torras-Sanvicens , J , Borroni , D , Sánchez-González , J M & Rocha-De-Lossada , C 2023 , ' Scheimpflug Corneal Densitometry Patterns at the Graft–Host Interface in DMEK and DSAEK : A 12-Month Longitudinal Comparative Study ' , Journal of clinical medicine , vol. 12 , no. 22 , 7133 . https://doi.org/10.3390/jcm12227133 |
Abstract: | Background: To compare corneal densitometry (CD) patterns at the graft–host interface between Descemet Membrane Endothelial Keratoplasty (DMEK) and Descemet Stripping Automated Endothelial Keratoplasty (DSAEK). Corneal densitometry is a quantitative assessment that objectively evaluates corneal clarity and optical quality by measuring the light backscatter from the cornea. Methods: Fifty-one eyes that received DMEK or DSAEK surgery for corneal endothelium dysfunction were evaluated. The primary endpoint included CD patterns at the graft–host interface, which were assessed by the Pentacam HR device at the center point of the corneal horizontal meridian (CDcentral), and at six points on the central circumference of the cornea (with a total diameter of 4 mm) (CDI,II,III,IV,V,VI). Secondary endpoints included the best-corrected distance visual acuity (BCDVA), central corneal thickness (CCT), and graft thickness (GT). All of the evaluations were performed at follow-up appointments one, three, six and twelve months after the procedure. Results: DMEK showed a significant overall CD reduction of −7.9 ± 8.5 grayscale unit (GSU) compared to DSAEK (p < 0.001). In addition, the DMEK group showed significantly lower CDCentral,I,II,III,IV,V,VI values at follow-up appointments one, three, six and twelve months after the procedure compared to the DSAEK group (p < 0.001). BCDVA, CCT and GT were in favor of the DMEK group with a mean value of 0.39 ± 0.35 LogMar, 552.2 ± 71.1 µm and 11.03 ± 1.4 µm, respectively (p < 0.001). Conclusions: CD patterns at the graft–host interface seem to be different depending on the endothelial keratoplasty procedure. This provides specific insight into CD changes in this critical region of surgery, which may provide a better understanding of the postoperative evolution of these patients. |
Description: | Publisher Copyright: © 2023 by the authors. |
DOI: | 10.3390/jcm12227133 |
ISSN: | 2077-0383 |
Appears in Collections: | Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure |
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Scheimpflug_Corneal_Densitometry_Patterns.pdf | 793.15 kB | Adobe PDF | View/Open |
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