Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Kristīne Rasnača | - |
dc.contributor.author | Aki Sakari Saarikivi | - |
dc.contributor.other | Medicīnas fakultāte | lv-LV |
dc.contributor.other | Faculty of Medicine | en-UK |
dc.date.accessioned | 2023-08-14T21:20:46Z | - |
dc.date.available | 2023-08-14T21:20:46Z | - |
dc.date.issued | 2023 | - |
dc.identifier.uri | https://dspace.rsu.lv/jspui/handle/123456789/14767 | - |
dc.description | Medicīna | lv-LV |
dc.description | Medicine | en-UK |
dc.description | Veselības aprūpe | lv-LV |
dc.description | Health Care | en-UK |
dc.description.abstract | Background and aims Subjects with congenital chloride diarrhea (CLD; a defect in solute carrier family 26 member 3 (SLC26A3)) are prone to inflammatory bowel disease (IBD). I investigated fecal microbiota in CLD. I also tested whether microbiota is modulated by supplementation with the short-chain fatty acid butyrate. Subjects and methods I recruited 8 patients under 18-years-old with CLD for an observational 3-week follow- up study. Thereafter, two of the children consented to oral butyrate substitution for a 3-week observational period. Fecal samples, collected once a week, were assayed for calprotectin and potential markers of inflammation, and studied by 16S ribosomal ribonucleic acid (rRNA) gene amplicon sequencing and compared to that of 19 healthy controls. Data on intestinal symptoms, diet and quality of life were collected. Conclusions Fecal microbiota is different between groups of CLD children (< 10-years of age), CLD adolescents (12-16-years of age) and healthy adult controls. Butyrate was poorly tolerated and showed no major effects on fecal microbiota or biomarkers in CLD. | lv-LV |
dc.description.abstract | Background and aims Subjects with congenital chloride diarrhea (CLD; a defect in solute carrier family 26 member 3 (SLC26A3)) are prone to inflammatory bowel disease (IBD). I investigated fecal microbiota in CLD. I also tested whether microbiota is modulated by supplementation with the short-chain fatty acid butyrate. Subjects and methods I recruited 8 patients under 18-years-old with CLD for an observational 3-week follow- up study. Thereafter, two of the children consented to oral butyrate substitution for a 3-week observational period. Fecal samples, collected once a week, were assayed for calprotectin and potential markers of inflammation, and studied by 16S ribosomal ribonucleic acid (rRNA) gene amplicon sequencing and compared to that of 19 healthy controls. Data on intestinal symptoms, diet and quality of life were collected. Conclusions Fecal microbiota is different between groups of CLD children (< 10-years of age), CLD adolescents (12-16-years of age) and healthy adult controls. Butyrate was poorly tolerated and showed no major effects on fecal microbiota or biomarkers in CLD. | en-UK |
dc.language.iso | en-UK | - |
dc.publisher | Rīgas Stradiņa universitāte | lv-LV |
dc.publisher | Rīga Stradiņš University | en-UK |
dc.subject | Microbiome | lv-LV |
dc.subject | CLD | lv-LV |
dc.subject | IBD | lv-LV |
dc.subject | Butyrate | lv-LV |
dc.subject | Microbiome | en-UK |
dc.subject | CLD | en-UK |
dc.subject | IBD | en-UK |
dc.subject | Butyrate | en-UK |
dc.title | The Effect of the Antibiotic Treatment received by the Mother during Childbirth on the Gut Microbiota of the Newborn and the Mother | en-UK |
dc.title.alternative | Dzemdību laikā mātes saņemtās antibakteriālās terapijas ietekme uz jaundzimušā un mātes zarnu trakta mikrobiotu | lv-LV |
dc.type | info:eu-repo/semantics/other | en-UK |
Appears in Collections: | Studējošo pētnieciskie darbi |
Files in This Item:
File | Size | Format | |
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Medicinas_fakultate_SSNMF_2023_Aki_Sakari_Saarikivi_033177.pdf | 806.09 kB | Adobe PDF | View/Open Request a copy![]() |
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