Research of HLA II Class DRB1, DQA1, DQB1 Genetic Markers on Patients with HIV Infection and AIDS. Summary of the Doctoral Thesis

Abstract

Aim of the present paper is to investigate the polymorphy of HLA II class DRB1, DQA1, DQB1 genes in different groups of HIV/AIDS infected patients, and also in groups of healthy inhabitants of Latvia. HLA genes perform the functions of immune reaction so they have an important role in processes connected with susceptibility of human body to HIV infection and the progress thereof. One of the hypotheses about AIDS explains that pathology develops in case of definite HLA heliotype. Prognosis of development of HIV infection is very important for efficient treatment and extension of patients’ survival. The thesis is devoted to correlation between infection with HIV and progress of opportunistic infections applying an up-to-date method – HLA genotyping (PĶR-SSP). It shall enable us to determine quite exactly the development of the complications during the illness and thus to offer the required help to the patients. The scheme of the present research for the first time will enable the use of the typing of the HLA immunogenetic markers for determination of risk of different pathologies or protective factors in the clinical practice, by displaying wider the clinical picture an enabling ordering therapy on the grounds of genetically determined susceptibility. This thesis shows the role of the major histocompatibility complex in predisposition and consistency of AIDS-sickness. The obtained results show that when identifying the allele class it is possible to conceive the molecular mechanisms of development of HIV infection, they can help also in forecasting of clinical results. The researched forms of HIV infection predisposition and the possible development of predisposition in AIDS phase have given an opportunity to understand the HLA system in case of AIDS progress.