Selenium, selenoprotein P, and oxidative stress levels in SARS-CoV-2 patients during illness and recovery
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Date
2022-04
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Abstract
Background: This study aimed to assess tendency of oxidative stress in COVID-19 patients depending on severity. Methods: The study was conducted with 80 post-COVID-19 disease patients and 40 acutely ill patients. Content of selenium in blood plasma was detected by a fluorimetric method with di-amino-naphthalene using acidic hydrolysis. Selenoprotein P, malondialdehyde and 4-hydroxynonenal and their metabolite adducts were evaluated by spectrophotometric methods using commercial assay kits. Results: Obtained results showed that selenium content in blood for post-COVID-19 disease patients was of a similar lower norm for Latvian inhabitants. Selenium and seleno-protein P contents for acute patients were significantly decreased compared with post-COVID-19 disease patients. Conclusion: In conclusion, COVID-19 involves induction of antioxidant systems—in case of severe disease, patients have significantly low concentration of selenium, seleno-protein P and higher level of oxidative stress, which, in turn, confirms the more intense formation of free radicals in the body.
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Publisher Copyright: © 2022, The Author(s).
Keywords
COVID-19, Free radicals, Oxidative stress, Selenium, Selenoprotein P, 3.1 Basic medicine, 1.4 Chemical sciences, 1.1. Scientific article indexed in Web of Science and/or Scopus database, Immunology, Pharmacology, Pharmacology (medical)
Citation
Skesters, A, Kustovs, D, Lece, A, Moreino, E, Petrosina, E & Rainsford, K D 2022, 'Selenium, selenoprotein P, and oxidative stress levels in SARS-CoV-2 patients during illness and recovery', Inflammopharmacology, vol. 30, no. 2, pp. 499-503. https://doi.org/10.1007/s10787-022-00925-z