Sperm chromatin structure and male fertility : biological and clinical aspects
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Date
2006-01
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Abstract
Aim: Sperm chromatin/DNA integrity is essential for the accurate transmission of paternal genetic information, and normal sperm chromatin structure is important for sperm fertilizing ability. The routine examination of semen, which includes sperm concentration, motility and morphology, does not identify defects in sperm chromatin structure. The origin of sperm DNA damage and a variety of methods for its assessment are described. Evaluation of sperm DNA damage appears to be a useful tool for assessing male fertility potential both in vivo and in vitro. The possible impact of sperm DNA defects on the offspring is also discussed.
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Keywords
Damage, DNA, Human, Infertility, Sperm, 3.1 Basic medicine, 3.2 Clinical medicine, 1.1. Scientific article indexed in Web of Science and/or Scopus database, Urology, SDG 3 - Good Health and Well-being
Citation
Ērenpreiss, J, Spano, M, Ērenpreisa, J, Bungum, M & Giwercman, A 2006, 'Sperm chromatin structure and male fertility : biological and clinical aspects', Asian Journal of Andrology, vol. 8, no. 1, pp. 11-29. https://doi.org/10.1111/j.1745-7262.2006.00112.x