Structural and functional analysis of bba03, borrelia burgdorferi competitive advantage promoting outer surface lipoprotein

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dc.contributor.authorFridmanis, Jēkabs
dc.contributor.authorBobrovs, Raitis
dc.contributor.authorBrangulis, Kalvis
dc.contributor.authorTārs, Kaspars
dc.contributor.authorJaudzems, Kristaps
dc.contributor.institutionDepartment of Human Physiology and Biochemistry
dc.date.accessioned2021-09-08T08:50:01Z
dc.date.available2021-09-08T08:50:01Z
dc.date.issued2020-10
dc.descriptionPublisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
dc.description.abstractBBA03 is a Borrelia burgdorferi outer surface lipoprotein encoded on one of the most conserved plasmids in Borrelia genome, linear plasmid 54 (lp54). Although many of its genes have been identified as contributing or essential for spirochete fitness in vivo, the majority of the proteins encoded on this plasmid have no known function and lack homologs in other organisms. In this paper, we report the solution NMR structure of the B. burgdorferi outer surface lipoprotein BBA03, which is known to provide a competitive advantage to the bacteria during the transmission from tick vector to mammalian host. BBA03 shows structural homology to other outer surface lipoproteins reflecting their genetic and evolutionary relatedness. Analysis of the structure reveals a pore in BBA03, which could potentially bind lipids.en
dc.description.statusPeer reviewed
dc.format.extent13
dc.format.extent2399855
dc.identifier.citationFridmanis, J, Bobrovs, R, Brangulis, K, Tārs, K & Jaudzems, K 2020, 'Structural and functional analysis of bba03, borrelia burgdorferi competitive advantage promoting outer surface lipoprotein', Pathogens, vol. 9, no. 10, 826, pp. 1-13. https://doi.org/10.3390/pathogens9100826
dc.identifier.doi10.3390/pathogens9100826
dc.identifier.issn2076-0817
dc.identifier.otherunpaywall: 10.3390/pathogens9100826
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6240
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85092483723&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofPathogens
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBBA03
dc.subjectCompetitive advantage
dc.subjectLp54
dc.subjectPfam54
dc.subjectSolution NMR structure
dc.subject3.1 Basic medicine
dc.subject1.6 Biological sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectImmunology and Allergy
dc.subjectMolecular Biology
dc.subjectGeneral Immunology and Microbiology
dc.subjectMicrobiology (medical)
dc.subjectInfectious Diseases
dc.subjectSDG 3 - Good Health and Well-being
dc.titleStructural and functional analysis of bba03, borrelia burgdorferi competitive advantage promoting outer surface lipoproteinen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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