Structural and functional analysis of bba03, borrelia burgdorferi competitive advantage promoting outer surface lipoprotein
No Thumbnail Available
Date
2020-10
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
BBA03 is a Borrelia burgdorferi outer surface lipoprotein encoded on one of the most conserved plasmids in Borrelia genome, linear plasmid 54 (lp54). Although many of its genes have been identified as contributing or essential for spirochete fitness in vivo, the majority of the proteins encoded on this plasmid have no known function and lack homologs in other organisms. In this paper, we report the solution NMR structure of the B. burgdorferi outer surface lipoprotein BBA03, which is known to provide a competitive advantage to the bacteria during the transmission from tick vector to mammalian host. BBA03 shows structural homology to other outer surface lipoproteins reflecting their genetic and evolutionary relatedness. Analysis of the structure reveals a pore in BBA03, which could potentially bind lipids.
Description
Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
Keywords
BBA03, Competitive advantage, Lp54, Pfam54, Solution NMR structure, 3.1 Basic medicine, 1.6 Biological sciences, 1.1. Scientific article indexed in Web of Science and/or Scopus database, Immunology and Allergy, Molecular Biology, General Immunology and Microbiology, Microbiology (medical), Infectious Diseases, SDG 3 - Good Health and Well-being
Citation
Fridmanis, J, Bobrovs, R, Brangulis, K, Tārs, K & Jaudzems, K 2020, 'Structural and functional analysis of bba03, borrelia burgdorferi competitive advantage promoting outer surface lipoprotein', Pathogens, vol. 9, no. 10, 826, pp. 1-13. https://doi.org/10.3390/pathogens9100826