Factors affecting facial development and formation of cleft lip and palate : a literature review
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Date
2020
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Abstract
The craniofacial region forms in a complicated developmental process regu-lated by multiple genes and growth factors. Disruption and dysregulation during facial development can lead to multiple congenital facial anomalies including cleft lip and palate. This literature review collects and analyses the existing information about the interaction of multiple growth factors and genes within the developing facial region and their association with facial pathology. The factors analysed in this review are DLX4, FOXE1, HOXB3, MSX2, PAX7, PAX9, RYK, SHH, SOX3, WNT3A, WNT9B and BARX1.
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Keywords
cleft lip, cleft palate, genes, growth factors, 3.1 Basic medicine, 1.1. Scientific article indexed in Web of Science and/or Scopus database
Citation
Vaivads, M, Balode, E & Pilmane, M 2020, 'Factors affecting facial development and formation of cleft lip and palate : a literature review', Papers on Anthropology, vol. 29, no. 2, pp. 22-35. https://doi.org/10.12697/poa.2020.29.2.02