Bioloģiskas izcelsmes kalcija saturoši biomateriāli .
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Date
2021
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Volume Title
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Rīgas Stradiņa universitāte
Rīga Stradiņš University
Rīga Stradiņš University
Abstract
Pētnieciskā darba nosaukums ir bioloģiskas izcelsmes kalcija saturoši biomateriāli.
Hidroksilapatīts, kas ir viena no galvenajām kaulu sastāvdaļām, tiek plaši izmantots dažādu protēžu un implantu izgatavošanā, jo tas ir biosaderīgs ar cilvēka organismu. Izpētot dabā pieejamos resursus, ir iespējams izstrādāt un sintezēt kauliem līdzīgus materiālus, lai tālāk izstrādātu vēl labākus biomateriālus.
Pētījuma mērķis ir izpētīt dzīvnieku un cilvēku kaulu struktūru, izmantojot pavājinātās pilnīgās atstarošanas Furjē transformācijas infrasarkanā spektroskopijas (ATR-FTIR) metodi, un salīdzināt iegūtos spektrus ar sintezētu kalcija fosfāta un kolagēna struktūru. Literatūras apskatā ir apkopota informācija par biomateriālu vispārīgo informāciju, kaulu un zobu sastāvu, cieto audu struktūras izmaiņām, Furjē transformācijas infrasarkanās spektroskopijas metodes piemērojamību.
Iegūtie rezultāti parādīja spektrālo daudzveidību galvenokārt neorganiskās daļas apgabalos, kas ilgākā laika posmā saglabājas relatīvi stabilāk nekā organiskā daļa.
The research theme is calcium-based biomaterials of biological origin. Hydroxyapatite, which is one of the main components of the bone, is widely used for manufacturing various implants and prostheses due to its biocompatibility with human organism. By exploring materials available in nature, it is possible to develop and synthesize bone-like materials than can be used to develop even better biomaterials. The objective was to study the structure of animal and human bones using Attenuated Total Reflection Fourier-transform spectroscopy (ATR-FTIR) method and compare spectra with synthesized calcium phosphate and collagen structure. Literature review summarizes the general information on biomaterials, bone and teeth composition and changes in structure over time, applicability of Fourier-transform infrared spectroscopy method. The results showed spectral diversity mainly due to the inorganic portion, which can remain relatively more stable than organic portion part over longer periods of time.
The research theme is calcium-based biomaterials of biological origin. Hydroxyapatite, which is one of the main components of the bone, is widely used for manufacturing various implants and prostheses due to its biocompatibility with human organism. By exploring materials available in nature, it is possible to develop and synthesize bone-like materials than can be used to develop even better biomaterials. The objective was to study the structure of animal and human bones using Attenuated Total Reflection Fourier-transform spectroscopy (ATR-FTIR) method and compare spectra with synthesized calcium phosphate and collagen structure. Literature review summarizes the general information on biomaterials, bone and teeth composition and changes in structure over time, applicability of Fourier-transform infrared spectroscopy method. The results showed spectral diversity mainly due to the inorganic portion, which can remain relatively more stable than organic portion part over longer periods of time.
Description
Farmācija
Pharmacy
Veselības aprūpe
Health Care
Pharmacy
Veselības aprūpe
Health Care
Keywords
kauli, kalcija hidroksilapatīts, kalcija fosfāts, biomateriāli, Furjē transformācijas infrasarkanā spektroskopija (FTIR)., bones, calcium hydroxyapatite, calcium phosphate, biomaterials, Fourier-transform infrared spectroscopy (FTIR).