Impact of Advanced Platelet-Rich Fibrin on Early Bone Healing After Endodontic Microsurgery : A Randomized Controlled Trial

Simple item page
dc.contributor.authorKārkle, Aleksandra
dc.contributor.authorNeimane, Laura
dc.contributor.authorZolovs, Maksims
dc.contributor.authorDambergs, Matīss
dc.contributor.authorMeistere, Dita
dc.contributor.authorVaškevica, Anete
dc.contributor.authorSlaidiņa, Anda
dc.contributor.institutionDepartment of Conservative Dentistry and Oral Health
dc.contributor.institutionStatistics Unit
dc.contributor.institutionDepartment of Prosthetic Dentistry
dc.date.accessioned2025-02-28T14:00:01Z
dc.date.available2025-02-28T14:00:01Z
dc.date.issued2025-02-20
dc.description.abstractBackground: Apical surgery can address periapical pathologies when conventional endodontic treatments fail. Advanced platelet-rich fibrin (A-PRF) has emerged as a regenerative material with the potential to enhance healing in periapical surgery. In this study, we evaluated the effect of A-PRF on periapical lesion healing using cone beam computed tomography (CBCT). Methods: A randomized controlled trial at Rīga Stradiņš University Institute of Stomatology included 43 participants (15 males, 28 females; mean age: 44 years) with periradicular lesions. Participants were divided into experimental and control groups. Baseline and follow-up CBCT imaging assessed lesion volumes at 6 and 12 months post-surgery. Results: Mean lesion volumes significantly decreased from 431.4 mm3 at baseline to 102.8 mm3 at 6 months and 49.2 mm3 at 12 months (p < 0.001). A-PRF did not significantly reduce the lesion sizes compared to the controls (p = 0.043), but was associated with reduced inflammation and enhanced soft tissue healing. Key confounders included gender and baseline lesion volume, with males exhibiting smaller lesion sizes postoperatively. Conclusions: The results suggest that A-PRF may not offer a significant advantage in terms of reducing defect size or improving radiographic resolution.en
dc.description.statusPeer reviewed
dc.format.extent17
dc.format.extent6349551
dc.identifier.citationKārkle, A, Neimane, L, Zolovs, M, Dambergs, M, Meistere, D, Vaškevica, A & Slaidiņa, A 2025, 'Impact of Advanced Platelet-Rich Fibrin on Early Bone Healing After Endodontic Microsurgery : A Randomized Controlled Trial', Diagnostics, vol. 15, no. 5, 516. https://doi.org/10.3390/diagnostics15050516
dc.identifier.doi10.3390/diagnostics15050516
dc.identifier.issn2075-4418
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/17146
dc.language.isoeng
dc.relation.ispartofDiagnostics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectapical surgery
dc.subjectadvanced platelet-rich fibrin
dc.subjectbone regeneration
dc.subjectCBCT
dc.subject3.2 Clinical medicine
dc.subject1.4. Reviewed scientific article published in Latvia or abroad in a scientific journal with an editorial board (including university editions)
dc.titleImpact of Advanced Platelet-Rich Fibrin on Early Bone Healing After Endodontic Microsurgery : A Randomized Controlled Trialen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Impact_of_Advanced_Platelet-Rich_Fibrin_on_Early_Bone_Healing_After_Endodontic_Microsurgery.pdf
Size:
6.06 MB
Format:
Adobe Portable Document Format
Download

Collections

Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure