Impact of Advanced Platelet-Rich Fibrin on Early Bone Healing After Endodontic Microsurgery : A Randomized Controlled Trial
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Date
2025-02-20
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Abstract
Background: Apical surgery can address periapical pathologies when conventional endodontic treatments fail. Advanced platelet-rich fibrin (A-PRF) has emerged as a regenerative material with the potential to enhance healing in periapical surgery. In this study, we evaluated the effect of A-PRF on periapical lesion healing using cone beam computed tomography (CBCT). Methods: A randomized controlled trial at Rīga Stradiņš University Institute of Stomatology included 43 participants (15 males, 28 females; mean age: 44 years) with periradicular lesions. Participants were divided into experimental and control groups. Baseline and follow-up CBCT imaging assessed lesion volumes at 6 and 12 months post-surgery. Results: Mean lesion volumes significantly decreased from 431.4 mm3 at baseline to 102.8 mm3 at 6 months and 49.2 mm3 at 12 months (p < 0.001). A-PRF did not significantly reduce the lesion sizes compared to the controls (p = 0.043), but was associated with reduced inflammation and enhanced soft tissue healing. Key confounders included gender and baseline lesion volume, with males exhibiting smaller lesion sizes postoperatively. Conclusions: The results suggest that A-PRF may not offer a significant advantage in terms of reducing defect size or improving radiographic resolution.
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apical surgery, advanced platelet-rich fibrin, bone regeneration, CBCT, 3.2 Clinical medicine, 1.4. Reviewed scientific article published in Latvia or abroad in a scientific journal with an editorial board (including university editions)
Citation
Kārkle, A, Neimane, L, Zolovs, M, Dambergs, M, Meistere, D, Vaškevica, A & Slaidiņa, A 2025, 'Impact of Advanced Platelet-Rich Fibrin on Early Bone Healing After Endodontic Microsurgery : A Randomized Controlled Trial', Diagnostics, vol. 15, no. 5, 516. https://doi.org/10.3390/diagnostics15050516