Comparison between diffusion-weighted sequences with selective and non-selective fat suppression in the evaluation of Crohn's disease activity : are they equally useful?

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dc.contributor.authorApine, Ilze
dc.contributor.authorPitura, Reinis
dc.contributor.authorFranckevica, Ivanda
dc.contributor.authorPokrotnieks, Juris
dc.contributor.authorKrūmiņa, Gaida
dc.contributor.institutionDepartment of Radiology
dc.contributor.institutionDepartment of Pathology
dc.contributor.institutionDepartment of Internal Diseases
dc.date.accessioned2021-08-27T13:00:01Z
dc.date.available2021-08-27T13:00:01Z
dc.date.issued2020-05-27
dc.descriptionPublisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
dc.description.abstractBackground: We compared the efficiency of two MRI diffusion weighted imaging (DWI) techniques: DWI with SPIR (DWI SPIR) and DWI with STIR (DWI STIR), to estimate their eligibility for quantitative assessment of Crohn's disease activity in children and adults. Methods: In inflamed terminal ileum segments ( n = 32 in adults, n = 46 in children), Magnetic Resonance Index of Activity (MaRIA) was calculated, ADC values of both DWI techniques were measured, and the corresponding Clermont scores calculated. ADC values of both DWI techniques were compared between both and within each patient group, assessing their mutual correlation. Correlations between MaRIA and the corresponding ADC values, and Clermont scores based on both DWI techniques were estimated. Results: No correlation between ADC of DWI SPIR and DWI STIR was observed (rho = 0.27, p = 0.13 in adults, rho = 0.20, p = 0.17 in children). The correlation between MaRIA and Clermont scores was strong in both techniques-in SPIR, rho = 0.93; p < 0.0005 in adults, rho = 0.98, p < 0.0005 in children, and, in STIR, rho = 0.89; p < 0.0005 in adults, rho = 0.95, p < 0.0005 in children. The correlation between ADC and MaRIA was moderate negative for DWI STIR (rho = 0.93, p < 0.0005 in adults, rho = 0.95, p < 0.0005 in children), but, in DWI STIR, no correlation between ADC and MaRIA score was observed in adults (rho = -0.001, p = 0.99), whereas children presented low negative correlation (rho = -0.374, p = 0.01). Conclusions: DWI STIR is not suitable for quantitative assessment of Crohn's disease activity both in children and adult patients.en
dc.description.statusPeer reviewed
dc.format.extent4892416
dc.identifier.citationApine, I, Pitura, R, Franckevica, I, Pokrotnieks, J & Krūmiņa, G 2020, 'Comparison between diffusion-weighted sequences with selective and non-selective fat suppression in the evaluation of Crohn's disease activity : are they equally useful?', Diagnostics, vol. 10, no. 6, 347. https://doi.org/10.3390/diagnostics10060347
dc.identifier.doi10.3390/diagnostics10060347
dc.identifier.otherunpaywall: 10.3390/diagnostics10060347
dc.identifier.otherMendeley: 6b3f80a0-cff9-3827-91f6-653dd85ce2b6
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6113
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85086021187&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofDiagnostics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectADC
dc.subjectClermont score
dc.subjectDWI
dc.subjectDWI fat suppression techniques
dc.subjectDWIBS
dc.subjectMR enterography
dc.subjectMaRIA
dc.subjectdiffusion-weighted imaging
dc.subjectterminal ileitis
dc.subject3.2 Clinical medicine
dc.subject1.6 Biological sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleComparison between diffusion-weighted sequences with selective and non-selective fat suppression in the evaluation of Crohn's disease activity : are they equally useful?en
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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