Comparison between diffusion-weighted sequences with selective and non-selective fat suppression in the evaluation of Crohn's disease activity : are they equally useful?
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2020-05-27
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Abstract
Background: We compared the efficiency of two MRI diffusion weighted imaging (DWI) techniques: DWI with SPIR (DWI SPIR) and DWI with STIR (DWI STIR), to estimate their eligibility for quantitative assessment of Crohn's disease activity in children and adults. Methods: In inflamed terminal ileum segments ( n = 32 in adults, n = 46 in children), Magnetic Resonance Index of Activity (MaRIA) was calculated, ADC values of both DWI techniques were measured, and the corresponding Clermont scores calculated. ADC values of both DWI techniques were compared between both and within each patient group, assessing their mutual correlation. Correlations between MaRIA and the corresponding ADC values, and Clermont scores based on both DWI techniques were estimated. Results: No correlation between ADC of DWI SPIR and DWI STIR was observed (rho = 0.27, p = 0.13 in adults, rho = 0.20, p = 0.17 in children). The correlation between MaRIA and Clermont scores was strong in both techniques-in SPIR, rho = 0.93; p < 0.0005 in adults, rho = 0.98, p < 0.0005 in children, and, in STIR, rho = 0.89; p < 0.0005 in adults, rho = 0.95, p < 0.0005 in children. The correlation between ADC and MaRIA was moderate negative for DWI STIR (rho = 0.93, p < 0.0005 in adults, rho = 0.95, p < 0.0005 in children), but, in DWI STIR, no correlation between ADC and MaRIA score was observed in adults (rho = -0.001, p = 0.99), whereas children presented low negative correlation (rho = -0.374, p = 0.01). Conclusions: DWI STIR is not suitable for quantitative assessment of Crohn's disease activity both in children and adult patients.
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Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
Keywords
ADC, Clermont score, DWI, DWI fat suppression techniques, DWIBS, MR enterography, MaRIA, diffusion-weighted imaging, terminal ileitis, 3.2 Clinical medicine, 1.6 Biological sciences, 1.1. Scientific article indexed in Web of Science and/or Scopus database
Citation
Apine, I, Pitura, R, Franckevica, I, Pokrotnieks, J & Krūmiņa, G 2020, 'Comparison between diffusion-weighted sequences with selective and non-selective fat suppression in the evaluation of Crohn's disease activity : are they equally useful?', Diagnostics, vol. 10, no. 6, 347. https://doi.org/10.3390/diagnostics10060347