3-Arilaziridīn-2-karbonskābes atvasinājumi un 3-arilaziridīn-2-il-ketoni: Aziridinēšanas metodes
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Date
2022
Authors
Journal Title
Journal ISSN
Volume Title
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Rīgas Stradiņa universitāte
Rīga Stradiņš University
Rīga Stradiņš University
Abstract
Aziridinēšanas reakcijās ir balstīta nozīmīga aziridīnu sintēzes metode. Pēdējās dekādēs šajā laukā ir sasniegts ievērojams progress. Augsti funkcionalizētie aziridīni, ieskaitot (3-arilaziridīn)-2-karbonil atvasinājumus, ir nozīmīgi gan medicīniskajā, gan arī sintēzes ķīmijā. Atrast jaunus pretvēža un pretvīrusu medikamentus un attīstīt efektīvas metodes gan pašu bioloģiski aktīvo savienojumu, gan to būvbloku sintēzē, ir viens no galvenajiem medicīniskās ķīmijas uzdevumiem. Šajā apskatā esam fokusējušies uz 3-arilaziridīnu ieguves aziridinēšanā balstītajām metodēm, apskatīts galvenokārt progress pēc 2000. gada.
Aziridination reactions represent a powerful tool in aziridine synthesis. Significant progress has been achieved in this field in the last decades, whereas highly functionalized aziridines including 3-arylated aziridine-2-carbonyl compounds play an important role in both medical and synthetic chemistry. The finding of new potential anti-cancer and antiviral drugs, as well as the development of efficient methods for synthesizing them and their appropriate building blocks, is one of the most important problems in medical chemistry. For the reasons listed, in the current review we have focused on the ways to obtain 3-arylated aziridines and on the recent advances (mainly since the year 2000) in the methodology of the synthesis of these compounds via aziridination.
Aziridination reactions represent a powerful tool in aziridine synthesis. Significant progress has been achieved in this field in the last decades, whereas highly functionalized aziridines including 3-arylated aziridine-2-carbonyl compounds play an important role in both medical and synthetic chemistry. The finding of new potential anti-cancer and antiviral drugs, as well as the development of efficient methods for synthesizing them and their appropriate building blocks, is one of the most important problems in medical chemistry. For the reasons listed, in the current review we have focused on the ways to obtain 3-arylated aziridines and on the recent advances (mainly since the year 2000) in the methodology of the synthesis of these compounds via aziridination.
Description
Medicīna
Medicine
Veselības aprūpe
Health Care
Medicine
Veselības aprūpe
Health Care
Keywords
Aziridīni, aziridinēšana, imīni, karbēni, nitrēni, aziridines; aziridination; imines; carbenes; nitrenes