Relationship; Celiac Disease, Infectious Agents and Microbiota
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Date
2020
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Rīgas Stradiņa universitāte
Rīga Stradiņš University
Rīga Stradiņš University
Abstract
Celiakija ir multifaktoriāla slimība, bet faktori, kas sekmē slimības attīstības mehānismu, pagaidām nav pilnībā izpētīti. Ir zināms, ka ģenētiski predisponētiem indivīdiem reaģējot uz glutēnu, veidojas T- šūnu mediēta atbildes reakcija zarnu traktā. Tās rezultātā rodas zarnu trakta bojājums ar bārkstiņu atrofiju un kriptu hiperplāziju, kas klīniski izpaužas kā malabsorbcija.
Ir zināms, ka celiakijas incidence pasaulē pieaug, bet šī fakta iemesli vēl nav pilnībā izpētīti. Veikti daudzi pētījumi par celiakijas saistību ar infekcijām un zarnu mikrobiomu. Pastāv teorija, ka zarnu mikrofloras traucējumi jeb disbioze varētu korelēt ar celiakijas attīstību.
Darba mērķis: Atrast iespējamo saistību starp infekciju izraisītājiem, zarnu mikrobiomu un celiakiju.
Darba hipotēze: Infekcijas veicina, bet zarnu mikrobioms kavē celiakijas attīstību.
Metode: Literatūras avotu izpēte, izmantojot datubāzes PubMed un Google Scholar.
Darba uzdevumi:
1) Aprakstīt celiakijas definīciju, patoģenēzi un diagnostikas metodes,
2) Analizēt pētījumu rezultātus par dažādu infekciju izraisītāju ietekmi uz celiakijas attīstību,
3) Izanalizēt pētījumu rezultātus par zarnu mikrofloras iespējamo aizsarglomu celiakijas attīstībā,
4) Apkopot un izdarīt secinājumus.
Celiac disease is a multifactorial disease without a complete known cause. What is known is that genetically predisposed individuals react to gluten. A T-cell mediated response leads to damage of intestine, villous atrophy, crypt hyperplasia and malabsorption. The issue we are facing today is a constantly increasing incidence rate of celiac disease, without a known cause. Multiple studies have been performed to confirm a connection between infections, intestinal microbiota and celiac disease. Recently, there are also theories that disturbances in intestinal microbiota, dysbiosis, might correlate with celiac disease. Aim: This review will focus on finding a correlation between infectious agents, intestinal microbiota and celiac disease. Hypothesis: Infectious agents induces, and intestinal microbiota protects against celiac disease onset. Methods: This literature review will use peer-reviewed articles found on Google Scholar and PubMed. Tasks: 1) To describe definition, pathogenesis and diagnostic of celiac disease. 2) To analyze results of studies about correlation between various infectious agents and development of celiac disease. 3) To analyze results of studies about protective role of intestinal microbiota in development of celiac disease. 4) To summarize results and make conclusions.
Celiac disease is a multifactorial disease without a complete known cause. What is known is that genetically predisposed individuals react to gluten. A T-cell mediated response leads to damage of intestine, villous atrophy, crypt hyperplasia and malabsorption. The issue we are facing today is a constantly increasing incidence rate of celiac disease, without a known cause. Multiple studies have been performed to confirm a connection between infections, intestinal microbiota and celiac disease. Recently, there are also theories that disturbances in intestinal microbiota, dysbiosis, might correlate with celiac disease. Aim: This review will focus on finding a correlation between infectious agents, intestinal microbiota and celiac disease. Hypothesis: Infectious agents induces, and intestinal microbiota protects against celiac disease onset. Methods: This literature review will use peer-reviewed articles found on Google Scholar and PubMed. Tasks: 1) To describe definition, pathogenesis and diagnostic of celiac disease. 2) To analyze results of studies about correlation between various infectious agents and development of celiac disease. 3) To analyze results of studies about protective role of intestinal microbiota in development of celiac disease. 4) To summarize results and make conclusions.
Description
Medicīna
Medicine
Veselības aprūpe
Health Care
Medicine
Veselības aprūpe
Health Care
Keywords
Celiakija, vīrusi, infekcijas, mikrobi, mikroflora, disbioze, antibiotikas., celiac disease, virus, infections, microbes, microbiota, dysbiosis, antibiotics