Bakteriofāgi un to loma mutes dobumā
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Date
2022
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Rīgas Stradiņa universitāte
Rīga Stradiņš University
Rīga Stradiņš University
Abstract
Cilvēka mutes dobums ir lieliska niša dažādu baktēriju attīstībai un proliferācijai, kas izskaidro faktu, kāpēc tas ir viens no blīvāk apdzīvotajām daļām cilvēka organismā. Bakteriofāgi nav izņēmums un tie dzīvo līdzās baktērijām, izmantojot cilvēka mutes dobumu kā perfekto vietu, kur inficēt sev atbilstošos saimniekorganismus. Tomēr, šo vīrusu loma mutes dobumā joprojām ir neskaidra, taču tie potenciāli varētu spēlēt svarīgu daļu mikrobioma līdzsvara nodrošināšanā un cilvēka veselībā kopumā. Līdzšinēji veiktie pētījumi vēsta par bakteriofāgu potenciālu lomu dažādu slimību gaitā, piemēram, periodontīta gadījumā. Nevien svarīga ir bakteriofāgu dabiskā loma mutes dobumā, bet arī to iespējas izmantot arvien jaunatklātos vīrusus, lai ārstētu dažādas mutes dobuma saslimšanas un potenciāli papildinātu vai aizstātu antibiotiku terapiju: jau iepriekšminēto periodontītu, kā arī novērstu kariesu, ārstētu inficētos zobu sakņu kanālus, apstrādātu implantus periimplantīta novēršanai. Šajā darbā apkopo, kas ir atklāts par bakteriofāgu lomu mutes dobumā, līdz šim atklātos bakteriofāgus un to lomu slimību progresijas iespaidošanā un iespējamo bakteriofāgu pielietojumu ārstēšanā, tās priekšrocības un trūkumus.
Human oral cavity is an excellent niche for proliferation of various bacteria, which makes it one of the most densely populated parts of the human body. Bacteriophages are no exception and live alongside bacteria, using the oral cavity as the perfect place to infect their appropriate hosts. However, the role of these viruses in the oral cavity remains unclear, but they could potentially play an important role in microbiome balance and human health in general. The studies conducted thus far indicate the potential role of bacteriophages in the course of various diseases, for example in the case of periodontitis. Not just the natural role of phages, but also the possibility of using the newly discovered phages to treat various diseases of oral cavity and potentially supplement or replace antibiotic therapy is also important: to treat the aforementioned periodontitis, as well as to prevent caries, treat infected tooth canals, prevent periimplantitis. In this review, author summarizes what has been discovered about the role of bacteriophages in the oral cavity, the bacteriophages discovered so far and their role in influencing the progression of diseases and the possible application of bacteriophages in treatment, its advantages and disadvantages.
Human oral cavity is an excellent niche for proliferation of various bacteria, which makes it one of the most densely populated parts of the human body. Bacteriophages are no exception and live alongside bacteria, using the oral cavity as the perfect place to infect their appropriate hosts. However, the role of these viruses in the oral cavity remains unclear, but they could potentially play an important role in microbiome balance and human health in general. The studies conducted thus far indicate the potential role of bacteriophages in the course of various diseases, for example in the case of periodontitis. Not just the natural role of phages, but also the possibility of using the newly discovered phages to treat various diseases of oral cavity and potentially supplement or replace antibiotic therapy is also important: to treat the aforementioned periodontitis, as well as to prevent caries, treat infected tooth canals, prevent periimplantitis. In this review, author summarizes what has been discovered about the role of bacteriophages in the oral cavity, the bacteriophages discovered so far and their role in influencing the progression of diseases and the possible application of bacteriophages in treatment, its advantages and disadvantages.
Description
Zobārstniecība
Dentistry
Veselības aprūpe
Health Care
Dentistry
Veselības aprūpe
Health Care
Keywords
bakteriofāgi, vīruss, mikrobioms, ārstēšana, bacteriophages, virus, microbiome, treatment