General influence of biphasic calcium phosphate on osteoporotic bone density
No Thumbnail Available
Date
2019-05-01
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Bone density of the femur body of rabbit was determined in vivo. Experimental osteoporosis was induced by ovariectomy and subsequent injections of methylprednisolone. In the greater trochanter region of right femur, defects were created and filled with granules of hydroxyapatite and tricalcium phosphate (HAP/TCP 70/30) or HAP/TCP 70/30 together with 5% strontium. After three months, the animals were euthanized. The bone mass density of the right and left body of femur was measured by cone beam computed tomography (CT) scan. The results of the study showed that the right femur of the rabbit, where biomaterials had been implanted, and the left femur, where no biomaterial implantation occurred, became denser after filling the defect with HAP/TCP 70/30 ceramic granules or 5% Sr modified HAP/TCP ceramic granules. There was no difference between operated and non-operated legs and HAP/TCP and HAP/TCP with 5% strontium groups.
Description
Funding Information: The study was supported by the National Research Programme No. 2014.10-4/VPP-3/21 “Multifunctional Components and composites, photonics and nanotechnology”. Project No. 4 “Nanocomponents and nanotechnologies for medical applications”. Publisher Copyright: © 2019 Vladislavs Ananjevs et al., published by Sciendo 2019. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.
Keywords
biphasic calcium phosphate, bone density, in vivo, osteoporosis, strontium, 3.2 Clinical medicine, 3.1 Basic medicine, 1.1. Scientific article indexed in Web of Science and/or Scopus database, General
Citation
Ananjevs, V, Ananjeva, A, Vetra, J, Skagers, A, Salma, I, Neimane, L & Kasyanov, V 2019, 'General influence of biphasic calcium phosphate on osteoporotic bone density', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 73, no. 2, pp. 185-188. https://doi.org/10.2478/prolas-2019-0029