DIMA 3.0 : Domain interaction map
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Date
2011-01
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Abstract
Domain Interaction MAp (DIMA, available at http:// webclu.bio.wzw.tum.de/ dima) is a database of predicted and known interactions between protein domains. It integrates 5807 structurally known interactions imported from the iPfam and 3did databases and 46 900 domain interactions predicted by four computational methods: domain phylogenetic profiling, domain pair exclusion algorithm correlated mutations and domain interaction prediction in a discriminative way. Additionally predictions are filtered to exclude those domain pairs that are reported as non-interacting by the Negatome database. The DIMA Web site allows to calculate domain interaction networks either for a domain of interest or for entire organisms, and to explore them interactively using the Flash-based Cytoscape Web software.
Description
Funding Information: Q.L. is supported by a scholarship of the German Academic Exchange Service (DAAD). Funding for open access charge: Helmholtz Gesellschaft. Copyright: Copyright 2011 Elsevier B.V., All rights reserved.
Keywords
1.6 Biological sciences, 2.2 Electrical engineering, Electronic engineering, Information engineering, 1.1. Scientific article indexed in Web of Science and/or Scopus database, Genetics
Citation
Luo, Q, Pagel, P, Vilne, B & Frishman, D 2011, 'DIMA 3.0 : Domain interaction map', Nucleic Acids Research, vol. 39, no. SUPPL. 1, pp. D724-D729. https://doi.org/10.1093/nar/gkq1200