From sweat to hope : The role of exercise-induced extracellular vesicles in cancer prevention and treatment

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dc.contributor.authorLlorente, Alicia
dc.contributor.authorBrokāne, Agnese
dc.contributor.authorMlynska, Agata
dc.contributor.authorPuurand, Marju
dc.contributor.authorSagini, Krizia
dc.contributor.authorFolkmane, Signe
dc.contributor.authorHjorth, Marit
dc.contributor.authorMartin-Gracia, Beatriz
dc.contributor.authorRomero, Silvana
dc.contributor.authorSkorinkina, Diana
dc.contributor.authorČampa, Mārtiņš
dc.contributor.authorCešeiko, Rūdolfs
dc.contributor.authorRomanchikova, Nadezhda
dc.contributor.authorKļaviņa, Aija
dc.contributor.authorKäämbre, Tuuli
dc.contributor.authorLinē, Aija
dc.contributor.institutionRīga Stradiņš University
dc.contributor.institutionLatvian Academy of Sport Education (LASE)
dc.date.accessioned2024-09-18T07:55:03Z
dc.date.available2024-09-18T07:55:03Z
dc.date.issued2024-08
dc.descriptionPublisher Copyright: © 2024 The Author(s). Journal of Extracellular Vesicles published by Wiley Periodicals LLC on behalf of International Society for Extracellular Vesicles.
dc.description.abstractThe benefits of regular physical exercise on cancer prevention, as well as reducing fatigue, treatment side effects and recurrence, and improving quality of life and overall survival of cancer patients, are increasingly recognised. Initial studies showed that the concentration of extracellular vesicles (EVs) increases during physical activity and that EVs carry biologically active cargo. These EVs are released by blood cells, skeletal muscle and other organs involved in exercise, thus suggesting that EVs may mediate tissue crosstalk during exercise. This possibility triggered a great interest in the study of the roles of EVs in systemic adaptation to exercise and in their potential applications in the prevention and treatment of various diseases, including cancer. This review presents studies exploring the concentration and molecular cargo of EVs released during exercise. Furthermore, we discuss putative stimuli that may trigger EV release from various cell types, the biological functions and the impact of exercise-induced EVs on cancer development and progression. Understanding the interplay between exercise, EVs, and cancer biology may offer insights into novel therapeutic strategies and preventive measures for cancer.en
dc.description.statusPeer reviewed
dc.format.extent31
dc.format.extent1663649
dc.identifier.citationLlorente, A, Brokāne, A, Mlynska, A, Puurand, M, Sagini, K, Folkmane, S, Hjorth, M, Martin-Gracia, B, Romero, S, Skorinkina, D, Čampa, M, Cešeiko, R, Romanchikova, N, Kļaviņa, A, Käämbre, T & Linē, A 2024, 'From sweat to hope : The role of exercise-induced extracellular vesicles in cancer prevention and treatment', Journal of Extracellular Vesicles, vol. 13, no. 8, e12500. https://doi.org/10.1002/jev2.12500
dc.identifier.doi10.1002/jev2.12500
dc.identifier.issn2001-3078
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/16691
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85202052595&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofJournal of Extracellular Vesicles
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcancer
dc.subjectEV protein cargo
dc.subjectEV RNA cargo
dc.subjectexercise-induced extracellular vesicles
dc.subjectmuscle-derived EVs
dc.subjectphysical exercise
dc.subject3.3 Health sciences
dc.subject1.6 Biological sciences
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectHistology
dc.subjectCell Biology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleFrom sweat to hope : The role of exercise-induced extracellular vesicles in cancer prevention and treatmenten
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview

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