From sweat to hope : The role of exercise-induced extracellular vesicles in cancer prevention and treatment
No Thumbnail Available
Date
2024-08
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The benefits of regular physical exercise on cancer prevention, as well as reducing fatigue, treatment side effects and recurrence, and improving quality of life and overall survival of cancer patients, are increasingly recognised. Initial studies showed that the concentration of extracellular vesicles (EVs) increases during physical activity and that EVs carry biologically active cargo. These EVs are released by blood cells, skeletal muscle and other organs involved in exercise, thus suggesting that EVs may mediate tissue crosstalk during exercise. This possibility triggered a great interest in the study of the roles of EVs in systemic adaptation to exercise and in their potential applications in the prevention and treatment of various diseases, including cancer. This review presents studies exploring the concentration and molecular cargo of EVs released during exercise. Furthermore, we discuss putative stimuli that may trigger EV release from various cell types, the biological functions and the impact of exercise-induced EVs on cancer development and progression. Understanding the interplay between exercise, EVs, and cancer biology may offer insights into novel therapeutic strategies and preventive measures for cancer.
Description
Publisher Copyright: © 2024 The Author(s). Journal of Extracellular Vesicles published by Wiley Periodicals LLC on behalf of International Society for Extracellular Vesicles.
Keywords
cancer, EV protein cargo, EV RNA cargo, exercise-induced extracellular vesicles, muscle-derived EVs, physical exercise, 3.3 Health sciences, 1.6 Biological sciences, 3.1 Basic medicine, 1.1. Scientific article indexed in Web of Science and/or Scopus database, Histology, Cell Biology, SDG 3 - Good Health and Well-being
Citation
Llorente, A, Brokāne, A, Mlynska, A, Puurand, M, Sagini, K, Folkmane, S, Hjorth, M, Martin-Gracia, B, Romero, S, Skorinkina, D, Čampa, M, Cešeiko, R, Romanchikova, N, Kļaviņa, A, Käämbre, T & Linē, A 2024, 'From sweat to hope : The role of exercise-induced extracellular vesicles in cancer prevention and treatment', Journal of Extracellular Vesicles, vol. 13, no. 8, e12500. https://doi.org/10.1002/jev2.12500