Peiseniece, EvijaZdanovskis, NaurisŠneidere, KristīneKostiks, AndrejsKarelis, GuntisPlatkājis, ArdisStepens, Ainārs2025-01-302025-01-302025-01-15Peiseniece, E, Zdanovskis, N, Šneidere, K, Kostiks, A, Karelis, G, Platkājis, A & Stepens, A 2025, 'Amygdala Nuclei Atrophy in Cognitive Impairment and Dementia : Insights from High-Resolution Magnetic Resonance Imaging', Medicina (Kaunas, Lithuania), vol. 61, no. 1, 130. https://doi.org/10.3390/medicina610101301010-660XPubMedCentral: PMC11766737https://dspace.rsu.lv/jspui/handle/123456789/17062Publisher Copyright: © 2025 by the authors.Background and Objectives: Cognitive impairment affects memory, reasoning, and problem-solving, with early detection being critical for effective management. The amygdala, a key structure in emotional processing and memory, may play a pivotal role in detecting cognitive decline. This study examines differences in amygdala nuclei volumes in patients with varying levels of cognitive performance to evaluate its potential as a biomarker.  Material and methods: This cross-sectional study of 35 participants was conducted and classified into three groups: the normal (≥26), moderate (15-25), and low (≤14) cognitive performance groups based on the Montreal Cognitive Assessment (MoCA) scores. High-resolution magnetic resonance imaging at 3.0 T scanner was used to assess amygdala nuclei volumes.  Results: Significant amygdala atrophy was observed in multiple amygdala nuclei across cognitive performance groups, with more pronounced changes in the low-performance group. The right hemisphere nuclei, including the lateral and basal nuclei, showed more significant differences, indicating their sensitivity to cognitive decline.  Conclusions: This study highlights the potential of amygdala nuclei atrophy as a biomarker for cognitive impairment. Additional research with larger sample sizes and longitudinal designs is needed to confirm these findings and determine their diagnostic value.1740961enginfo:eu-repo/semantics/openAccessHumansAmygdala/diagnostic imagingMaleFemaleMagnetic Resonance Imaging/methodsCross-Sectional StudiesCognitive Dysfunction/etiologyAtrophyAgedMiddle AgedDementia/diagnostic imagingNeuropsychological TestsAged, 80 and over3.2 Clinical medicine1.1. Scientific article indexed in Web of Science and/or Scopus database/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article10.3390/medicina61010130https://www-webofscience-com.db.rsu.lv/wos/alldb/full-record/MEDLINE:39859112http://www.scopus.com/inward/record.url?scp=85215798421&partnerID=8YFLogxK