Sabelnikovs, OlegsNikitina-Zake, LieneVanags, Indulis2021-10-202021-10-202008-01Sabelnikovs, O, Nikitina-Zake, L & Vanags, I 2008, 'Association of Interleukin 6 Promoter Polymorphism (-174G/C) with IL-6 Level and Outcome in Severe Sepsis', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 62, no. 4/5, pp. 162-164. https://doi.org/10.2478/v10046-008-0019-91407-009Xhttps://dspace.rsu.lv/jspui/handle/123456789/6676Interleukin (IL-6) is a key cytokine in the pathogenesis of severe sepsis. The importance of a regulatory polymorphism within the IL-6 promoter remains unclear in these patients. The aim of the study was to determine if IL-6 (-174 G/C) promoter polymorphism has an effect on IL-6plasma level and outcome of severe sepsis. The study was conducted in general ICU of Stradiņš Clinical University Hospital. A total of 103 critically ill patients with confirmed severe sepsis were prospectively included. Association analysis of the IL-6 (-174C) allele with serum level and clinical outcome was performed. We found no differences in genotype distribution between survivors and nonsurvivors. The serum IL-6 level was significantly higher in nonsurvivors compared with survivors. We found an association of genotype with the IL-6 level in non survivors, but not in survivors. Our findings show a functional significance of IL-6 promoter polymorphisms in nonsurviving severe sepsis patients.358717enginfo:eu-repo/semantics/openAccess174 C/G polymorphisminterleukine-6severe sepsis3.2 Clinical medicine1.1. Scientific article indexed in Web of Science and/or Scopus databaseGeneral/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article10.2478/v10046-008-0019-9http://www.scopus.com/inward/record.url?scp=84994774832&partnerID=8YFLogxK