Oleinika, KristineSlisere, BaibaCatalán, DiegoRosser, Elizabeth C.2023-04-192023-04-192022-12Oleinika, K, Slisere, B, Catalán, D & Rosser, E C 2022, 'B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity', Clinical and Experimental Immunology, vol. 210, no. 3, pp. 263-272. https://doi.org/10.1093/cei/uxac0790009-9104https://dspace.rsu.lv/jspui/handle/123456789/11716Obesity increases the risk of type 2 diabetes mellitus, cardiovascular disease, fatty liver disease, and cancer. It is also linked with more severe complications from infections, including COVID-19, and poor vaccine responses. Chronic, low-grade inflammation and associated immune perturbations play an important role in determining morbidity in people living with obesity. The contribution of B cells to immune dysregulation and meta-inflammation associated with obesity has been documented by studies over the past decade. With a focus on human studies, here we consolidate the observations demonstrating that there is altered B cell subset composition, differentiation, and function both systemically and in the adipose tissue of individuals living with obesity. Finally, we discuss the potential factors that drive B cell dysfunction in obesity and propose a model by which altered B cell subset composition in obesity underlies dysfunctional B cell responses to novel pathogens.1473728enginfo:eu-repo/semantics/openAccess3.1 Basic medicine3.2 Clinical medicine1.1. Scientific article indexed in Web of Science and/or Scopus databaseSDG 3 - Good Health and Well-being/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview10.1093/cei/uxac079https://www-webofscience-com.db.rsu.lv/wos/alldb/full-record/WOS:000846912200001