Sekretarjovs, JurijsKalējs, MārtiņšRudzītis, AinārsBrečs, IvarsSorokins, HermanisSkuja, SandraStradiņš, PēterisGroma, Valērija2021-06-032021-06-032017-09-18Sekretarjovs, J, Kalējs, M, Rudzītis, A, Brečs, I, Sorokins, H, Skuja, S, Stradiņš, P & Groma, V 2017, 'Long-term complications evidenced studying the explanted Gore® HELEX® atrial septal defect occluder seven years after implantation : a case report', Papers on Anthropology, vol. 26, no. 2, pp. 105-112. https://doi.org/10.12697/poa.2017.26.2.111736-7646unpaywall: 10.12697/poa.2017.26.2.11https://dspace.rsu.lv/jspui/handle/123456789/4689We present the results of the first morphological study of a Gore® HELEX® Septal Occluder 30 mm that was explanted seven years after interventional implantation due to a significant left-to-right shunt (7 mm) which resulted from the stretching of the concomitant patent foramen ovale by the occluder after atrial septal defect closure. Complete endothelialization of the surface of the device, the formation of the connective tissue around the implant, minor chronic inflammation, the appearance of foreign body giant cells and weakened myocardial cells adjacent to the implant as well as enhanced expression of matrix metalloproteinases were demonstrated.1423500enginfo:eu-repo/semantics/openAccessAtrial septal defectGore® HELEX® septal occludematrix metalloproteinases, myocardium3.1 Basic medicine3.2 Clinical medicine1.1. Scientific article indexed in Web of Science and/or Scopus database/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article10.12697/poa.2017.26.2.11