Bubin, RomanUljanovs, RomansStrumfa, Ilze2023-05-202023-05-202023-04Bubin, R, Uljanovs, R & Strumfa, I 2023, 'Cancer Stem Cells in Pancreatic Ductal Adenocarcinoma', International Journal of Molecular Sciences, vol. 24, no. 8, 7030, pp. 1-23. https://doi.org/10.3390/ijms240870301661-6596https://dspace.rsu.lv/jspui/handle/123456789/12147Publisher Copyright: © 2023 by the authors.The first discovery of cancer stem cells (CSCs) in leukaemia triggered active research on stemness in neoplastic tissues. CSCs represent a subpopulation of malignant cells, defined by unique properties: a dedifferentiated state, self-renewal, pluripotency, an inherent resistance to chemo- and radiotherapy, the presence of certain epigenetic alterations, as well as a higher tumorigenicity in comparison with the general population of cancer cells. A combination of these features highlights CSCs as a high-priority target during cancer treatment. The presence of CSCs has been confirmed in multiple malignancies, including pancreatic ductal adenocarcinoma, an entity that is well known for its dismal prognosis. As the aggressive course of pancreatic carcinoma is partly attributable to treatment resistance, CSCs could contribute to adverse outcomes. The aim of this review is to summarize the current information regarding the markers and molecular features of CSCs in pancreatic ductal adenocarcinoma and the therapeutic options to remove them.232902243enginfo:eu-repo/semantics/openAccesscancer stem cellsepigeneticsepithelial–mesenchymal transitionpancreatic ductal adenocarcinomasignalling pathways3.1 Basic medicine3.2 Clinical medicine1.1. Scientific article indexed in Web of Science and/or Scopus databaseCatalysisMolecular BiologySpectroscopyComputer Science ApplicationsPhysical and Theoretical ChemistryOrganic ChemistryInorganic ChemistrySDG 3 - Good Health and Well-being/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview10.3390/ijms24087030http://www.scopus.com/inward/record.url?scp=85156182621&partnerID=8YFLogxK