Isaguliants, MariaBayurova, EkaterinaAvdoshina, DaryaKondrashova, AllaChiodi, FrancescaPalefsky, Joel M.2021-04-092021-04-092021-01-02Isaguliants, M, Bayurova, E, Avdoshina, D, Kondrashova, A, Chiodi, F & Palefsky, J M 2021, 'Oncogenic Effects of HIV-1 Proteins, Mechanisms Behind', Cancers, vol. 13, no. 2, 305, pp. 1-24. https://doi.org/10.3390/cancers130203052072-6694Mendeley: 6aa5681c-9841-3827-8ce6-bb9ff4af863cunpaywall: 10.3390/cancers13020305https://dspace.rsu.lv/jspui/handle/123456789/3724Funding Information: Funding: This study was supported the Russian Fund for Basic Research grants 17_54_30002 and 20‐04‐01034 to M.I., Latvian Science Council grants LZP‐2018/2‐0308 and LZP‐2020/2‐0376 to M.I., Funding Information: and NCI R01CA 217715 to J.P.The work of Francesca Chiodi is supported by a grant from the Swe‐ dish Medical Research Council (Francesca Chiodi; Vetenskapsrådet 2019‐01169). Publisher Copyright: © 2021 by the authors.People living with human immunodeficiency virus (HIV-1) are at increased risk of developing cancer, such as Kaposi sarcoma (KS), non-Hodgkin lymphoma (NHL), cervical cancer, and other cancers associated with chronic viral infections. Traditionally, this is linked to HIV-1-induced immune suppression with depletion of CD4+ T-helper cells, exhaustion of lymphopoiesis and lymphocyte dysfunction. However, the long-term successful implementation of antiretroviral therapy (ART) with an early start did not preclude the oncological complications, implying that HIV-1 and its antigens are directly involved in carcinogenesis and may exert their effects on the background of restored immune system even when present at extremely low levels. Experimental data indicate that HIV-1 virions and single viral antigens can enter a wide variety of cells, including epithelial. This review is focused on the effects of five viral proteins: envelope protein gp120, accessory protein negative factor Nef, matrix protein p17, transactivator of transcription Tat and reverse transcriptase RT. Gp120, Nef, p17, Tat, and RT cause oxidative stress, can be released from HIV-1-infected cells and are oncogenic. All five are in a position to affect “innocent” bystander cells, specifically, to cause the propagation of (pre)existing malignant and malignant transformation of normal epithelial cells, giving grounds to the direct carcinogenic effects of HIV-1.241278161enginfo:eu-repo/semantics/openAccesshuman immunodeficiency virus type 1epithelial cellscarcinogenicityoxidative stressreactive oxygen speciesgp120TatNefmatrix protein p17reverse transcriptase3.2 Clinical medicine1.1. Scientific article indexed in Web of Science and/or Scopus databaseSDG 3 - Good Health and Well-being/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview10.3390/cancers13020305http://www.scopus.com/inward/record.url?scp=85099594195&partnerID=8YFLogxK