Ballesteros-Sánchez, AntonioSánchez-González, José MaríaTedesco, Giovanni RobertoRocha-de-Lossada, CarlosMurano, GianlucaSpinelli, AntonioMazzotta, CosimoBorroni, Davide2025-01-022025-01-022024-03Ballesteros-Sánchez, A, Sánchez-González, J M, Tedesco, G R, Rocha-de-Lossada, C, Murano, G, Spinelli, A, Mazzotta, C & Borroni, D 2024, 'Evaluating GlicoPro Tear Substitute Derived from Helix aspersa Snail Mucus in Alleviating Severe Dry Eye Disease : A First-in-Human Study on Corneal Esthesiometry Recovery and Ocular Pain Relief', Journal of clinical medicine, vol. 13, no. 6, 1618. https://doi.org/10.3390/jcm130616182077-0383https://dspace.rsu.lv/jspui/handle/123456789/16993Publisher Copyright: © 2024 by the authors.Background: To evaluate the effects of 10% GlicoPro tear substitute therapy in patients with severe dry eye disease (DED). Methods: In this prospective longitudinal study, 30 individuals receiving 10% GlicoPro four times daily for DED were evaluated. The ocular surface disease index (OSDI) questionnaire, average non-invasive break-up time (A-NIBUT), non-anesthetic and anesthetic corneal esthesiometry (CE), ocular pain, and the presence of conjunctivochalasis (CCH) were used as clinical endpoints. Treatment compliance using dosing diaries and AEs was assessed. Results: A significant improvement was observed in the clinical endpoints: the ΔOSDI questionnaire was −39.27 ± 13.22 [−65 to −15] points, ΔA-NIBUT was 3.10 ± 1.31 [1 to 5] s, Δnon-anesthetic CE was 14 ± 6.35 [5 to 25] mm, and Δanesthetic CE was 13 ± 5.35 [5 to 20] mm (p < 0.001 for all comparisons). Ocular pain was reduced in 92.5% of the patients at the end of the follow-up. However, there was no change in the presence of CCH. In addition, all the patients were fully compliant with the dosing and no AEs related to the use of the 10% GlicoPro tear substitute were reported. Conclusions: The 10% GlicoPro tear substitute has the potential to achieve beneficial effects in ocular surface treatments.925278enginfo:eu-repo/semantics/openAccesscorneal esthesiometrydry eye diseaseHelix aspersaocular paintear substitute3.2 Clinical medicine1.1. Scientific article indexed in Web of Science and/or Scopus databaseGeneral MedicineSDG 3 - Good Health and Well-being/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article10.3390/jcm13061618http://www.scopus.com/inward/record.url?scp=85189034491&partnerID=8YFLogxK