Panina, AleksandraLigere, ElīnaAleksejeva, ElīnaDavidsone, ZaneCebure, ElizabeteErdmane, Irina2023-11-302023-11-302023-01-24Panina, A, Ligere, E, Aleksejeva, E, Davidsone, Z, Cebure, E & Erdmane, I 2023, 'Eosinophilic Granulomatosis with Polyangiitis in an 8-year-old Girl Manifesting as Hypereosinophilic Syndrome with Myocarditis, Stroke, and Subsequent Orbital Involvement', Acta medica Lituanica, vol. 30, no. 1, pp. 45-52. https://doi.org/10.15388/Amed.2023.30.1.51392-0138https://dspace.rsu.lv/jspui/handle/123456789/15018Copyright © 2023 A. Panina Aleksandra, Ligere Elīna, Aleksejeva Elīna, Davidsone Zane, Cebure Elizabete, Erdmane Irina. Published by Vilnius University Press.Hypereosinophilic syndrome (HES) is a heterogeneous group of disorders characterized by peripheral blood eosinophilia of 1.5 × 109/L (1,500/μL) or greater, with evidence of end-organ damage attributable to eosinophilia (e.g., heart, liver or lung) with no other cause for the end-organ damage [1]. Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare disorder that may affect multiple organ systems (lungs, heart, kidneys, or the nervous system). The disorder is characterized by hypereosinophilia in the blood and tis-sues, inflammation of blood vessels (vasculitis), and the development of inflammatory nodular lesions called granulomatosis [2]. We report a case with a 9-year-old girl presenting with severe hypereosinophilia, ischemic stroke, right-sided hemiparesis and myocarditis treated with methylprednisolone, enoxaparin, rivaroxaban and carvedilol. The patient recovered successfully from myocarditis and stroke but manifested with right-sided orbital involvement as pre-and post-septal orbital cellulitis 10 months later with necrotizing granu-lomatous perivascular chronic infiltration with eosinophilic infiltration treated with methylprednisolone and subsequent mepolizumab with successful remission of orbital involvement, but severe exogenous Cushing’s syndrome and myocardial fibrosis.82517341enginfo:eu-repo/semantics/openAccessChurg–Strauss syn-dromeeosinophilic myocarditisorbital involvementpaediatric hypereosinophilic syndromestroke3.2 Clinical medicine1.1. Scientific article indexed in Web of Science and/or Scopus databaseGeneral Medicine/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article10.15388/Amed.2023.30.1.5http://www.scopus.com/inward/record.url?scp=85164140016&partnerID=8YFLogxK