Increased Numbers of CD4+CD25+ and CD8+CD25+ T-Cells in Peripheral Blood of Patients with Rheumatoid Arthritis with Parvovirus B19 Infection

Naciute, MildaMaciunaite, GabrieleMieliauskaite, DianaRugiene, RitaZinkeviciene, AukseMauricas, MykolasMurovska, ModraGirkontaite, Irute2021-06-032021-06-032017-03-01Naciute, M, Maciunaite, G, Mieliauskaite, D, Rugiene, R, Zinkeviciene, A, Mauricas, M, Murovska, M & Girkontaite, I 2017, 'Increased Numbers of CD4 + CD25 + and CD8 + CD25 + T-Cells in Peripheral Blood of Patients with Rheumatoid Arthritis with Parvovirus B19 Infection', In Vivo, vol. 31, no. 2, pp. 181-185. https://doi.org/10.21873/invivo.110430258-851Xhttps://dspace.rsu.lv/jspui/handle/123456789/4690Aim: To investigate T-cell subpopulations in peripheral blood of human parvovirus B19 DNA-positive (B19+) and-negative (B19-) patients with rheumatoid arthritis (RA) and healthy persons. Patients and Methods: Blood samples were collected from 115 patients with RA and 47 healthy volunteers; 27 patients with RA and nine controls were B19+. Cluster of differentiation (CD) 4, 8, 25 and 45RA were analyzed on blood cells. CD25 expression on CD4+CD45RA+, CD4+CD45RA-, CD8+CD45RA+, CD8+CD45RA- subsets were analyzed by flow cytometry. Results: The percentage of CD25low and CD25hi cells was increased on CD4+CD45RA+, CD4+CD45RA-T-cells and the percentage of CD25+ cells was increased on CD8+CD45RA+, CD8+CD45RA-T-cells of B19+ patients with RA in comparison with B19- patients and controls. Conclusion: Raised levels of CD4 and CD8 regulatory T-cells in B19+ RA patients could cause downregulation of antiviral clearance mechanisms and lead to activation of persistent human parvovirus B19 infection in patients with RA.52391876enginfo:eu-repo/semantics/openAccessCD4CD25CD8CD25Parvovirus B19Rheumatoid arthritisTreg1.6 Biological sciences3.1 Basic medicine1.1. Scientific article indexed in Web of Science and/or Scopus databaseGeneral Biochemistry,Genetics and Molecular BiologyPharmacologySDG 3 - Good Health and Well-beingIncreased Numbers of CD4+CD25+ and CD8+CD25+ T-Cells in Peripheral Blood of Patients with Rheumatoid Arthritis with Parvovirus B19 Infection/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article10.21873/invivo.11043http://www.scopus.com/inward/record.url?scp=85016078479&partnerID=8YFLogxK