Plinta, AelitaTretjakovs, PēterisSvirskis, ŠimonsLogina, InāraGersone, GitaJurka, AntraMikelsone, IndraBlumfelds, LeonsMackēvičs, VitoldsBahs, Guntis2022-10-142022-10-142022-10Plinta, A, Tretjakovs, P, Svirskis, Š, Logina, I, Gersone, G, Jurka, A, Mikelsone, I, Blumfelds, L, Mackēvičs, V & Bahs, G 2022, 'Association of Body Mass Index, Blood Pressure, and Interictal Serum Levels of Cytokines in Migraine with and without Aura', Journal of Clinical Medicine, vol. 11, no. 19, 5696, pp. 1-12. https://doi.org/10.3390/jcm111956962077-0383Mendeley: a49d6b5b-8d9c-371d-8142-b5aef676a28chttps://dspace.rsu.lv/jspui/handle/123456789/9663Publisher Copyright: © 2022 by the authors.The aim of the study was to clarify correlations between body mass index (BMI), blood pressure (BP), and serum levels of cytokines in female migraine patients. A total of 14 migraineurs with aura, and 12 without aura during their interictal period were compared with 25 controls. Interleukin-8 (IL-8), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), matrix metalloproteinase-9 (MMP-9), interferon gamma (IFN-γ), monocyte chemoattractant protein-1 (MCP-1), transforming growth factor alpha (TGF-α), and plasminogen activator inhibitor-1 (PAI-1) were measured. Migraineurs have elevated levels of IL-8, but decreased serum levels of PAI-1 and sICAM-1 during the interictal period, regardless of aura. BMI correlates with BP, and also with IFN-γ and MMP-9 only in patients with aura. There are three correlations in migraine patients with aura that are absent in patients without aura: between IL-8 and PAI-1; MMP-9 and IL-8; and IL-8 and sICAM-1. Migraineurs without aura, on the other hand, have correlations that patients with aura do not have (between PAI-1 and MCP-1, sICAM-1; between MMP-9 and sICAM-1, MCP-1; between TGF-α and PAI-1, MMP-9, sICAM-1; between sICAM-1 and MMP-9, PAI-1, MCP-1; as well as between sVCAM-1 and MCP-1). PAI-1, TGF, and MMP-9 could be used as biomarkers to distinguish migraineurs from healthy individuals.123291373432913734enginfo:eu-repo/semantics/openAccess3.1 Basic medicine1.1. Scientific article indexed in Web of Science and/or Scopus database/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article10.3390/jcm11195696http://www.scopus.com/inward/record.url?scp=85139761533&partnerID=8YFLogxK