Zrelovs, NikitaUstinova, MontaSilamikelis, IvarsBirzniece, LigaMegnis, KasparsRovite, VitaFreimane, LaumaSilamikele, LailaAnsone, LauraPjalkovskis, JanisFridmanis, DavidsVilne, BaibaPriedite, MartaCaica, AnastasijaGavars, MikusPerminov, DmitryStorozenko, JelenaSavicka, OksanaDimina, ElinaDumpis, UgaKlovins, Janis2021-09-282021-09-282021Zrelovs, N, Ustinova, M, Silamikelis, I, Birzniece, L, Megnis, K, Rovite, V, Freimane, L, Silamikele, L, Ansone, L, Pjalkovskis, J, Fridmanis, D, Vilne, B, Priedite, M, Caica, A, Gavars, M, Perminov, D, Storozenko, J, Savicka, O, Dimina, E, Dumpis, U & Klovins, J 2021, 'First Report on the Latvian SARS-CoV-2 Isolate Genetic Diversity', Frontiers in Medicine, vol. 8, 626000. https://doi.org/10.3389/fmed.2021.6260002296-858XPubMedCentral: PMC8055824https://dspace.rsu.lv/jspui/handle/123456789/6452Copyright © 2021 Zrelovs, Ustinova, Silamikelis, Birzniece, Megnis, Rovite, Freimane, Silamikele, Ansone, Pjalkovskis, Fridmanis, Vilne, Priedite, Caica, Gavars, Perminov, Storozenko, Savicka, Dimina, Dumpis and Klovins.Remaining a major healthcare concern with nearly 29 million confirmed cases worldwide at the time of writing, novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused more than 920 thousand deaths since its outbreak in China, December 2019. First case of a person testing positive for SARS-CoV-2 infection within the territory of the Republic of Latvia was registered on 2nd of March 2020, 9 days prior to the pandemic declaration by WHO. Since then, more than 277,000 tests were carried out confirming a total of 1,464 cases of coronavirus disease 2019 (COVID-19) in the country as of 12th of September 2020. Rapidly reacting to the spread of the infection, an ongoing sequencing campaign was started mid-March in collaboration with the local testing laboratories, with an ultimate goal in sequencing as much local viral isolates as possible, resulting in first full-length SARS-CoV-2 isolate genome sequences from the Baltics region being made publicly available in early April. With 133 viral isolates representing ~9.1% of the total COVID-19 cases during the "first coronavirus wave" in the country (early March, 2020-mid-September, 2020) being completely sequenced as of today, here, we provide a first report on the genetic diversity of Latvian SARS-CoV-2 isolates.4522551enginfo:eu-repo/semantics/openAccess3.1 Basic medicine3.3 Health sciences1.1. Scientific article indexed in Web of Science and/or Scopus database/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article10.3389/fmed.2021.626000http://www.scopus.com/inward/record.url?scp=85104606644&partnerID=8YFLogxK