Trapp, MaximilianeMihailova, AnnaKakurina, NatalijaMurovska, Modra2021-10-212021-10-212021-04-01Trapp, M, Mihailova, A, Kakurina, N & Murovska, M 2021, 'Significance of hypouricaemia in the development of neurodegenerative diseases', Proceedings of the Latvian Academy of Sciences Section B Natural Exact and Applied Sciences, vol. 75, no. 2, pp. 92-98. https://doi.org/10.2478/prolas-2021-00152255-890Xhttps://dspace.rsu.lv/jspui/handle/123456789/6696Publisher Copyright: © 2021 Sciendo. All rights reserved.Hypouricaemia has received relatively little attention in the literature. As a result, there is lessawareness or understanding of the potential risks of low uric acid levels. Emerging research indi-cates that normal uric acid levels may have an antioxidative and neuroprotective effect. Thisstudy aims to investigate possible associations between hypouricaemia and neurodegenerativedisease. Data was collected from seventy-seven outpatients and inpatients who underwent rou-tine uric acid testing, who were then stratified into patients with and without neurodegenerativedisease. Patients with renal pathologies and patients using uric acid altering medications were ex-cluded from the study. There was a significant difference in the prevalence of Alzheimer’s diseasebetween hypouricemic and normouricemic patients (p= 0.001), however there was no differencein the prevalence of vascular dementia (p= 0.45). This study provides evidence that hypouricae-mia has potential effects on health, specifically on the rate of neurodegenerative diseases suchas Alzheimer’s disease and gives weight to the potential neuroprotective role of uric acid.7190370enginfo:eu-repo/semantics/openAccessuric acid, Alzheimer’s disease, vascular dementia3.2 Clinical medicine1.1. Scientific article indexed in Web of Science and/or Scopus database/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article10.2478/prolas-2021-0015http://www.scopus.com/inward/record.url?scp=85106290705&partnerID=8YFLogxK