Gončars, ValdisKalnbērzs, KonstantīnsJākobsons, ĒrksBriede, IevaBlums, KristapsĒrglis, KristapsĒrglis, MārtiņšPatetko, LieneMuižnieks, IndriķisĒrglis, Andrejs2021-06-112021-06-112018-08-01Gončars, V, Kalnbērzs, K, Jākobsons, Ē, Briede, I, Blums, K, Ērglis, K, Ērglis, M, Patetko, L, Muižnieks, I & Ērglis, A 2018, 'New Modalities in Knee Osteoarthritis Treatment Using Autologous Bone Marrow-Derived Mononuclear Cells', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 72, no. 4, pp. 207-215. https://doi.org/10.2478/prolas-2018-00661407-009Xhttps://dspace.rsu.lv/jspui/handle/123456789/4916Publisher Copyright: © 2018 Valdis Gončars et al., published by Sciendo 2018.The clinical effects on knee osteoarthritis (OA) symptoms and tissue structure were evaluated after bone marrow-derived mononuclear cell intraarticular injection. A group of 32 patients with 34 knee joints in stage II-III osteoarthritis were treated by intraarticular injection of mononuclear cell suspension. Clinical results were obtained by KOOS (Knee Osteoarthritis Outcome Score) and KSS (Knee Society Score) scores during a 12 months follow-up period. Radiological evaluation was performed using magnetic resonance imaging. A comparison with a control group of 28 patients treated with routinely used three hyaluronic acid intra-articular injections was made. No adverse effects were observed after the bone marrow derived mononuclear cells (BM-MNC) injection. At the end point of the follow up all score results had improved, compared to those at to the starting point. 65% of patients maintained minimal perceptible clinical improvement of the score results. The Whole Organ Magnetic Resonance Imaging Score showed improvement from 44.31 to 42.93 points (p < 0.05) during a 6-7 month period. Comparing score results to the control group, a statistically significant (p < 0.05) improvement in the KOOS pain subscale score at the 6 and 12 months was observed in the mononuclear cell group. BM-MNC injection leads to a decrease of knee OA symptoms and slows changes in structure of the degenerative joint tissue.91702093enginfo:eu-repo/semantics/openAccessbone marrow mononuclear cellshyaluronic acidknee osteoarthritismesenchymal stem cellsregenerative therapy3.1 Basic medicine3.2 Clinical medicine1.1. Scientific article indexed in Web of Science and/or Scopus databaseGeneral/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article10.2478/prolas-2018-0066http://www.scopus.com/inward/record.url?scp=85064158087&partnerID=8YFLogxK