Svalbe, BaibaGrinberga, SolveigaStelfa, GundegaVavers, EdijsZvejniece, BaibaSevostjanovs, EduardsDambrova, MaijaZvejniece, Liga2021-04-282021-04-282019-12Svalbe, B, Grinberga, S, Stelfa, G, Vavers, E, Zvejniece, B, Sevostjanovs, E, Dambrova, M & Zvejniece, L 2019, 'Data on analysis of MK-801 bioavailability in mouse plasma and brain tissue by ultra-performance liquid chromatography-tandem mass spectrometry', Data in Brief, vol. 27, 104623. https://doi.org/10.1016/j.dib.2019.1046232352-3409https://dspace.rsu.lv/jspui/handle/123456789/3949Funding Information: This research was supported by the European Regional Development Fund (ERDF) project No. 1.1.1.2/VIAA/1/16/244 “The role of sigma-1 receptor in sexual behavior”. Publisher Copyright: © 2019 The Author(s)MK-801, a N-methyl-D-aspartate receptor antagonist, is widely used in animal preclinical experiments to induce memory and learning impairments and schizophrenia-like behavior. In the present study, we compared the plasma and brain tissue concentrations of MK-801 after intraperitoneal (i.p.) or subcutaneous (s.c.) administration at a dose of 0.1 mg/kg in male ICR mice. Moreover, these data present the optimization of ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for the analysis of MK-801 in biological samples. Procedures for the preparation of brain tissue and plasma samples and instrumental analysis are described. This article is related to a research article entitled “Effects of the N-methyl-D-aspartate receptor antagonist, MK-801, on spatial memory and influence of the route of administration” [1].456019enginfo:eu-repo/semantics/openAccessBioavailabilityi.p. and s.c. administration routeMiceMK-801UPLC-MS/MS3.1 Basic medicine1.1. Scientific article indexed in Web of Science and/or Scopus databaseGeneral/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article10.1016/j.dib.2019.104623http://www.scopus.com/inward/record.url?scp=85068505948&partnerID=8YFLogxK