Sidhom, ElgaPilmane, Mara2021-04-222021-04-222017-09-01Sidhom, E & Pilmane, M 2017, 'Detection of TGF-β1, HGF, IGF-1 and IGF-1R in cleft affected mucosa of the lip', Open Dermatology Journal, vol. 11, pp. 46-52. https://doi.org/10.2174/18743722017110100461874-3722https://dspace.rsu.lv/jspui/handle/123456789/3907Publisher Copyright: © 2017 Sidhom and Pilmane.Background: Orofacial clefts are one of the most common birth defects with multifactorial and only partly understood morphopathogenesis. Objective: The aim of this study was to evaluate the presence of TGF-β1, HGF, IGF-1 and IGF-1R in cleft affected mucosa of the lip. Methods: Lip mucosa tissue samples were obtained during surgical cleft correction from seven 2 to 6 months old children. Prepared tissue sections were stained by immunohistochemistry for TGF-β1, HGF, IGF-1 and IGF-1R. The intensity of staining was graded semiquantitatively. Results: We found numerous TGF-β1 and HGF-containing epithelial and connective tissue cells, moderate number of IGF-1 immunoreactive cells and even less pronounced presence of IGF-1R-positive cells. Conclusion: TGF-β1 and HGF are present in defective epithelia and soft tissue in cleft affected lip. Expressions of IGF-1 and IGF-1R show significant differences, and both factors play a role in the morphopathogenesis of clefts.7407835enginfo:eu-repo/semantics/openAccessCleftHGFIGF-1IGF-1RLip mucosaOrofacial defectsTGF-β13.1 Basic medicine3.2 Clinical medicine1.1. Scientific article indexed in Web of Science and/or Scopus databaseDermatology/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article10.2174/1874372201711010046http://www.scopus.com/inward/record.url?scp=85032740544&partnerID=8YFLogxK