Lucāne, ZaneKursīte, MirdzaŠablinskis, KristapsGailīte, LindaKurjāne, Nataļja2023-10-272023-10-272023-10-25Lucāne, Z, Kursīte, M, Šablinskis, K, Gailīte, L & Kurjāne, N 2023, 'COVID-19 Vaccination Coverage and Factors Influencing Vaccine Hesitancy among Patients with Inborn Errors of Immunity in Latvia: A Mixed-Methods Study', Vaccines, vol. 11, no. 11, 1637. https://doi.org/10.3390/vaccines111116372076-393XMendeley: b89242d8-4847-3a4b-b994-5ee25f212628https://dspace.rsu.lv/jspui/handle/123456789/14923Publisher Copyright: © 2023 by the authors.Background: The European Society for Immunodeficiencies recommends that all patients with inborn errors of immunity (IEI) without contraindications should receive SARS-CoV-2 vaccination. The aim of this study was to investigate the reasons that discourage IEI patients from receiving the recommended vaccination and to assess vaccination coverage among IEI patients in Latvia. Methods: In this multicenter mixed-methods study, the vaccination status of all patients with IEI within two tertiary centers in Latvia was reviewed using electronic health records. Semi-structured interviews were conducted with 16 IEI patients who did not undergo vaccination, and a thematic analysis was performed. Results: A total of 341 patients (49.3% female; median age 19.7 years (IQR:17)) were included in the quantitative part. The proportion of fully vaccinated individuals aged ≥ 12 years was 66.8%–70.9% with patients with selective IgA deficiency and 58.8% with other IEI (χ² = 14.12, p < 0.001). The proportion of fully vaccinated individuals aged 5–11 years was 11.1%. Age was associated with vaccination status: younger patients were found to have a significantly lower likelihood of receiving vaccination (U = 8585, p < 0.001). The five main themes identified were as follows: (1) fear and uncertainty; (2) risk and benefit assessment: COVID-19 vaccine—is it worth it? (3) external influences: the dark horse of the decision-making—people around us; (4) individuals against the system; and (5) beliefs about vaccination and COVID-19. Under-representation of certain IEI groups and recall bias are possible limitations of this study. Conclusions: While most reasons for hesitancy were similar to those previously described in the general population, disease-specific concerns were also identified.18328206enginfo:eu-repo/semantics/openAccessvaccine hesitancyvaccination coverageCOVID-19 vaccineSARS-CoV-2 vaccineinborn errors of immunityprimary imunodeficienciesLatviaprimary immunodeficiencies3.3 Health sciences1.1. Scientific article indexed in Web of Science and/or Scopus databaseDrug DiscoveryInfectious DiseasesPharmacology (medical)PharmacologyImmunologySDG 3 - Good Health and Well-being/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article10.3390/vaccines11111637https://www.mendeley.com/catalogue/b89242d8-4847-3a4b-b994-5ee25f212628/http://www.scopus.com/inward/record.url?scp=85178164787&partnerID=8YFLogxK